Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells

This study sought to investigate whether reactive oxygen species (ROS)–generating reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to calcific aortic valve disease (CAVD) or whether celastrol, a natural Nox2 inhibitor, may provide potential therapeutic target for CAVD...

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Detalles Bibliográficos
Autores principales: Liu, Huibing, Wang, Libo, Pan, Yating, Wang, Xuehui, Ding, Yuan, Zhou, Chaoyuan, Shah, Ajay M., Zhao, Guoan, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000868/
https://www.ncbi.nlm.nih.gov/pubmed/32043019
http://dx.doi.org/10.1016/j.jacbts.2019.10.004

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