Cargando…

Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer

AIM: To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC). PATIENTS & METHODS: A total of 76 formalin-fixed paraffin-embedded tissue...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ihemelandu, Chukwuemeka, Naeem, Aisha, Parasido, Erika, Berry, Deborah, Chaldekas, Krysta, Harris, Brent T, Rodriguez, Olga, Albanese, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Medicine Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000925/ https://www.ncbi.nlm.nih.gov/pubmed/32038737 http://dx.doi.org/10.2217/crc-2019-0009

Ejemplares similares

3089 Clinicopathologic and Prognostic Significance of LGR5, a Cancer Stem cell Marker in Peritoneal Metastasis of a Colorectal Origin
por: Ihemelandu, Chukwuemeka
Publicado: (2019)

Characterization of the effects of defined, multidimensional culture conditions on conditionally reprogrammed primary human prostate cells
por: Tricoli, Lucas, et al.
Publicado: (2017)

Overexpression of cancer stem cell marker Lgr5 in colorectal cancer patients and association with clinicopathological findings
por: Shekarriz, Ramin, et al.
Publicado: (2019)

Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway
por: Naeem, Aisha, et al.
Publicado: (2022)

Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient‐derived primary prostate cells
por: Naeem, Aisha, et al.
Publicado: (2020)

LGR5 expression and clinicopathological features of the invasive front in the fat infiltration area of pancreatic cancer
por: Kamakura, Masato, et al.
Publicado: (2022)

LGR5 and LGR6 in stem cell biology and ovarian cancer
por: Schindler, Adam J., et al.
Publicado: (2017)

The tumor immune microenvironment of primary and metastatic HER2− positive breast cancers utilizing gene expression and spatial proteomic profiling
por: Schlam, Ilana, et al.
Publicado: (2021)

The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer
por: Gzil, Arkadiusz, et al.
Publicado: (2020)

Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients
por: AbdelMageed, Manar, et al.
Publicado: (2021)

Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy
por: Xu, Liangliang, et al.
Publicado: (2019)

Management of malignancy-associated bowel obstruction by cervical esophagostomy and total parenteral nutrition, case series of 2 patients
por: Sugarbaker, Paul H., et al.
Publicado: (2018)

Transcriptome profiling of LGR5 positive colorectal cancer cells
por: Hirsch, Daniela, et al.
Publicado: (2014)

Canine Epithelial Skin Tumours: Expression of the Stem Cell Markers Lgr5, Lgr6 and Sox9 in Light of New Cancer Stem Cell Theories
por: Bongiovanni, Laura, et al.
Publicado: (2020)

Lgr6: From Stemness to Cancer Progression
por: Cortesi, Emanuela, et al.
Publicado: (2019)

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
por: Fumagalli, Arianna, et al.
Publicado: (2020)

Stem Cell Markers in Neuroblastoma—An Emerging Role for LGR5
por: Forgham, Helen, et al.
Publicado: (2015)

Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
por: Chen, Qing, et al.
Publicado: (2014)

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
por: Morgan, RG, et al.
Publicado: (2018)

Immunohistochemical Evaluation of β-Catenin Marker in Papillary Thyroid Cancer: Clinicopathologic Significance
por: Ziari, Katayoun, et al.
Publicado: (2018)

The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells
por: Waye, Sarah, et al.
Publicado: (2015)

Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer
por: Valladares-Ayerbes, Manuel, et al.
Publicado: (2012)

Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1
por: Shin, Jae Hun, et al.
Publicado: (2021)

Variants of the PPARD Gene and Their Clinicopathological Significance in Colorectal Cancer
por: Ticha, Ivana, et al.
Publicado: (2013)

Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer
por: Zeng, Jun, et al.
Publicado: (2017)

Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer
por: Su, Shasha, et al.
Publicado: (2015)

Expression of 5-HT Relates to Stem Cell Marker LGR5 in Patients with Gastritis and Gastric Cancer
por: Niu, Qian, et al.
Publicado: (2022)

LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation
por: Tsai, Yu-Hwai, et al.
Publicado: (2016)

The clinicopathological significance of neurogenesis in breast cancer
por: Zhao, Qianqian, et al.
Publicado: (2014)

Lgr5-positive cells in the lung and their clinical significance in patients with lung adenocarcinoma
por: Zhang, Xiaohan, et al.
Publicado: (2016)

Colonic Stem Cells Expression of Lgr5 and CD133 Proteins as Predictive Markers in Colorectal Cancer among Egyptian Patients
por: Rosiq, Saed, et al.
Publicado: (2018)

Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival
por: Wu, Xiao-Song, et al.
Publicado: (2012)

p53 in colorectal cancer: clinicopathological correlation and prognostic significance.
por: Scott, N., et al.
Publicado: (1991)

Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer
por: Hu, Tinghua, et al.
Publicado: (2013)

The Clinicopathological Significance of miR-133a in Colorectal Cancer
por: Wan, Timothy Ming-Hun, et al.
Publicado: (2014)

Upregulation of STC2 in colorectal cancer and its clinicopathological significance
por: Zhang, Chunxiao, et al.
Publicado: (2019)

Clinicopathological Significances and Prognostic Value of PPFIA4 in Colorectal Cancer
por: Fu, Fangmei, et al.
Publicado: (2023)

Clinicopathological Significances and Prognostic Role of Intratumoral Budding in Colorectal Cancers
por: Kang, Guhyun, et al.
Publicado: (2022)

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
por: Lee, Joo-Hyeon, et al.
Publicado: (2017)

Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells
por: Nakata, Susumu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0lvb0tpsva3vnht3jfs08ehvaa