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Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization

BACKGROUND: Fulminant myocarditis is the critical form of myocarditis that is often associated with heart failure, malignant arrhythmia, and circulatory failure. Patients with fulminant myocarditis who end up with severe multiple organic failure and death are not rare. AIM: To analyze the predictors...

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Autores principales: Kang, Tie-Duo, Ren, Yan-Long, Zhao, Han, Ning, Shang-Qiu, Liu, Wen-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000935/
https://www.ncbi.nlm.nih.gov/pubmed/32047773
http://dx.doi.org/10.12998/wjcc.v8.i2.255
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author Kang, Tie-Duo
Ren, Yan-Long
Zhao, Han
Ning, Shang-Qiu
Liu, Wen-Xian
author_facet Kang, Tie-Duo
Ren, Yan-Long
Zhao, Han
Ning, Shang-Qiu
Liu, Wen-Xian
author_sort Kang, Tie-Duo
collection PubMed
description BACKGROUND: Fulminant myocarditis is the critical form of myocarditis that is often associated with heart failure, malignant arrhythmia, and circulatory failure. Patients with fulminant myocarditis who end up with severe multiple organic failure and death are not rare. AIM: To analyze the predictors of in-hospital major adverse cardiovascular events (MACE) in patients diagnosed with fulminant myocarditis. METHODS: We included a cohort of adult patients diagnosed with fulminant myocarditis who were admitted to Beijing Anzhen Hospital from January 2007 to December 2017. The primary endpoint was defined as in-hospital MACE, including death, cardiac arrest, cardiac shock, and ventricular fibrillation. Baseline demographics, clinical history, characteristics of electrocardiograph and ultrasonic cardiogram, laboratory examination, and treatment were recorded. Multivariable logistic regression was used to examine risk factors for in-hospital MACE, and the variables were subsequently assessed by the area under the receiver operating characteristic curve (AUC). RESULTS: The rate of in-hospital MACE was 40%. Multivariable logistic regression analysis revealed that baseline QRS duration > 120 ms was the independent risk factor for in-hospital MACE (odds ratio = 4.57, 95%CI: 1.23-16.94, P = 0.023). The AUC of QRS duration > 120 ms for predicting in-hospital MACE was 0.683 (95%CI: 0.532-0.833, P = 0.03). CONCLUSION: Patients with fulminant myocarditis has a poor outcome. Baseline QRS duration is the independent risk factor for poor outcome in those patients.
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spelling pubmed-70009352020-02-11 Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization Kang, Tie-Duo Ren, Yan-Long Zhao, Han Ning, Shang-Qiu Liu, Wen-Xian World J Clin Cases Case Control Study BACKGROUND: Fulminant myocarditis is the critical form of myocarditis that is often associated with heart failure, malignant arrhythmia, and circulatory failure. Patients with fulminant myocarditis who end up with severe multiple organic failure and death are not rare. AIM: To analyze the predictors of in-hospital major adverse cardiovascular events (MACE) in patients diagnosed with fulminant myocarditis. METHODS: We included a cohort of adult patients diagnosed with fulminant myocarditis who were admitted to Beijing Anzhen Hospital from January 2007 to December 2017. The primary endpoint was defined as in-hospital MACE, including death, cardiac arrest, cardiac shock, and ventricular fibrillation. Baseline demographics, clinical history, characteristics of electrocardiograph and ultrasonic cardiogram, laboratory examination, and treatment were recorded. Multivariable logistic regression was used to examine risk factors for in-hospital MACE, and the variables were subsequently assessed by the area under the receiver operating characteristic curve (AUC). RESULTS: The rate of in-hospital MACE was 40%. Multivariable logistic regression analysis revealed that baseline QRS duration > 120 ms was the independent risk factor for in-hospital MACE (odds ratio = 4.57, 95%CI: 1.23-16.94, P = 0.023). The AUC of QRS duration > 120 ms for predicting in-hospital MACE was 0.683 (95%CI: 0.532-0.833, P = 0.03). CONCLUSION: Patients with fulminant myocarditis has a poor outcome. Baseline QRS duration is the independent risk factor for poor outcome in those patients. Baishideng Publishing Group Inc 2020-01-26 2020-01-26 /pmc/articles/PMC7000935/ /pubmed/32047773 http://dx.doi.org/10.12998/wjcc.v8.i2.255 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Control Study
Kang, Tie-Duo
Ren, Yan-Long
Zhao, Han
Ning, Shang-Qiu
Liu, Wen-Xian
Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
title Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
title_full Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
title_fullStr Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
title_full_unstemmed Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
title_short Risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
title_sort risk factors for adverse cardiac events in adults with fulminant myocarditis during hospitalization
topic Case Control Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000935/
https://www.ncbi.nlm.nih.gov/pubmed/32047773
http://dx.doi.org/10.12998/wjcc.v8.i2.255
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