Experimental Evolution Generates Novel Oncolytic Vesicular Stomatitis Viruses with Improved Replication in Virus-Resistant Pancreatic Cancer Cells

Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here, using a directed evolution approach with our two pre...

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Detalles Bibliográficos
Autores principales: Seegers, Sara L., Frasier, Connor, Greene, Sarah, Nesmelova, Irina V., Grdzelishvili, Valery Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000975/
https://www.ncbi.nlm.nih.gov/pubmed/31694943
http://dx.doi.org/10.1128/JVI.01643-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000975/
https://www.ncbi.nlm.nih.gov/pubmed/31694943
http://dx.doi.org/10.1128/JVI.01643-19

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