Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4(+) T Cell Pathogenicity and Suppresses Autoimmunity

Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macrophage metabolic remodeling in inflammation, but its role i...

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Detalles Bibliográficos
Autores principales: Angiari, Stefano, Runtsch, Marah C., Sutton, Caroline E., Palsson-McDermott, Eva M., Kelly, Beth, Rana, Nisha, Kane, Harry, Papadopoulou, Gina, Pearce, Erika L., Mills, Kingston H.G., O'Neill, Luke A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001035/
https://www.ncbi.nlm.nih.gov/pubmed/31761564
http://dx.doi.org/10.1016/j.cmet.2019.10.015

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