Cargando…

Is tau in the absence of amyloid on the Alzheimer’s continuum?: A study of discordant PET positivity

The amyloid cascade model of Alzheimer’s disease posits the primacy of amyloid beta deposition preceding tau-mediated neurofibrillary tangle formation. The amyloid-tau-neurodegeneration biomarker-only diagnostic framework similarly requires the presence of amyloid beta for a diagnosis on the Alzheim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weigand, Alexandra J, Bangen, Katherine J, Thomas, Kelsey R, Delano-Wood, Lisa, Gilbert, Paul E, Brickman, Adam M, Bondi, Mark W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001143/ https://www.ncbi.nlm.nih.gov/pubmed/32051933 http://dx.doi.org/10.1093/braincomms/fcz046

Ejemplares similares

Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta
por: Weigand, Alexandra J, et al.
Publicado: (2022)

Higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in Vietnam‐era veterans: A Department of Defense Alzheimer's Disease Neuroimaging Initiative (DOD‐ADNI) study
por: Clark, Alexandra L., et al.
Publicado: (2021)

White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia
por: Edwards, Lauren, et al.
Publicado: (2023)

Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines
por: Thomas, Kelsey R., et al.
Publicado: (2021)

Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint
por: Thomas, Kelsey R., et al.
Publicado: (2022)

Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum
por: Doré, Vincent, et al.
Publicado: (2022)

Prediabetes Is Associated With Brain Hypometabolism and Cognitive Decline in a Sex-Dependent Manner: A Longitudinal Study of Nondemented Older Adults
por: Sundermann, Erin E., et al.
Publicado: (2021)

Hypertension and Alzheimer’s disease: indirect effects through circle of Willis atherosclerosis
por: Eglit, Graham M L, et al.
Publicado: (2020)

Characterization of Alzheimer’s tau biomarker discordance using plasma, CSF, and PET
por: Guo, Yu, et al.
Publicado: (2021)

Arterial Stiffening Moderates the Relationship Between Type-2 Diabetes Mellitus and White Matter Hyperintensity Burden in Older Adults With Mild Cognitive Impairment
por: Werhane, Madeleine L., et al.
Publicado: (2021)

What’s the cut-point?: a systematic investigation of tau PET thresholding methods
por: Weigand, Alexandra J., et al.
Publicado: (2022)

Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
por: Bangen, Katherine J., et al.
Publicado: (2017)

Pathological functional impairment: Neuropsychological correlates of the shared variance between everyday functioning and brain volumetrics
por: Fellows, Robert P., et al.
Publicado: (2022)

Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes
por: Bangen, Katherine J., et al.
Publicado: (2018)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

Correction to: Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta
Publicado: (2023)

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum
por: Coomans, Emma M., et al.
Publicado: (2023)

Discordant Amyloid Status Diagnosis in Alzheimer’s Disease
por: García-Vallés, Lorena, et al.
Publicado: (2022)

Topographical Heterogeneity of Alzheimer’s Disease Based on MR Imaging, Tau PET, and Amyloid PET
por: Jeon, Seun, et al.
Publicado: (2019)

Brain Derived Neurotrophic Factor Interacts with White Matter Hyperintensities to Influence Processing Speed and Hippocampal Volume in Older Adults
por: Brenner, Einat K., et al.
Publicado: (2023)

Evidence for the Utility of Actuarial Neuropsychological Criteria Across the Continuum of Normal Aging, Mild Cognitive Impairment, and Dementia
por: Graves, Lisa V., et al.
Publicado: (2020)

Intrusion errors moderate the relationship between blood glucose and regional cerebral blood flow in cognitively unimpaired older adults
por: Thomas, Kelsey R., et al.
Publicado: (2021)

Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia
por: Bangen, Katherine J., et al.
Publicado: (2021)

Longitudinal tau PET in ageing and Alzheimer’s disease
por: Jack, Clifford R, et al.
Publicado: (2018)

Detection of Alzheimer's disease amyloid beta 1‐42, p‐tau, and t‐tau assays
por: van Harten, Argonde C., et al.
Publicado: (2021)

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status
por: Shen, Xue-Ning, et al.
Publicado: (2021)

Cognitive Heterogeneity and Risk of Progression in Data-Driven Subtle Cognitive Decline Phenotypes
por: Thomas, Kelsey R., et al.
Publicado: (2022)

Predicting amyloid PET and tau PET stages with plasma biomarkers
por: Jack, Clifford R, et al.
Publicado: (2023)

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences
por: de Wilde, Arno, et al.
Publicado: (2019)

Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment
por: Chandra, Avinash, et al.
Publicado: (2019)

Deep learning improves utility of tau PET in the study of Alzheimer's disease
por: Zou, James, et al.
Publicado: (2021)

Deep learning-based amyloid PET positivity classification model in the Alzheimer’s disease continuum by using 2-[(18)F]FDG PET
por: Kim, Suhong, et al.
Publicado: (2021)

Decreased myelin content of the fornix predicts poorer memory performance beyond vascular risk, hippocampal volume, and fractional anisotropy in nondemented older adults
por: Bangen, Katherine J., et al.
Publicado: (2021)

Individualized network analysis: A novel approach to investigate tau PET using graph theory in the Alzheimer’s disease continuum
por: Protas, Hillary, et al.
Publicado: (2023)

Blast-Exposed Veterans With Mild Traumatic Brain Injury Show Greater Frontal Cortical Thinning and Poorer Executive Functioning
por: Clark, Alexandra L., et al.
Publicado: (2018)

Cerebral amyloid‐β load is associated with neurodegeneration and gliosis: Mediation by p‐tau and interactions with risk factors early in the Alzheimer's continuum
por: Salvadó, Gemma, et al.
Publicado: (2021)

The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study
por: Ismail, Rola, et al.
Publicado: (2020)

Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy?
por: Balck, Alexander, et al.
Publicado: (2019)

Exploring discordant low amyloid beta and high neocortical tau positron emission tomography cases
por: Krishnadas, Natasha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ohjsg88hgftoelplen3re67p41