Prevention of doxorubicin-induced Cardiotoxicity by pharmacological non-hypoxic myocardial preconditioning based on Docosahexaenoic Acid (DHA) and carvedilol direct antioxidant effects: study protocol for a pilot, randomized, double-blind, controlled trial (CarDHA trial)

BACKGROUND: Anthracycline-induced cardiotoxicity (AIC), a condition associated with multiple mechanisms of damage, including oxidative stress, has been associated with poor clinical outcomes. Carvedilol, a β-blocker with unique antioxidant properties, emerged as a strategy to prevent AIC, but recent...

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Detalles Bibliográficos
Autores principales: Carrasco, Rodrigo, Ramirez, María Cristina, Nes, Kjersti, Schuster, Andrés, Aguayo, Rubén, Morales, Marcelo, Ramos, Cristobal, Hasson, Daniel, Sotomayor, Camilo G., Henriquez, Pablo, Cortés, Ignacio, Erazo, Marcia, Salas, Claudio, Gormaz, Juan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001267/
https://www.ncbi.nlm.nih.gov/pubmed/32019575
http://dx.doi.org/10.1186/s13063-019-3963-6

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