Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of these tauopathies, tau spreads throughout the brain via synaptically-connected pathways. Such propagation of pathology is thought to be mediated by tau...

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Detalles Bibliográficos
Autores principales: Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M., de Silva, Rohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001291/
https://www.ncbi.nlm.nih.gov/pubmed/32019610
http://dx.doi.org/10.1186/s40478-020-0884-2

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