Hypothalamic lipoma and growth hormone deficiency

BACKGROUND: Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. CASE PRESENTATION: A 7-year-old boy was referred for short...

Descripción completa

Detalles Bibliográficos
Autores principales: Rochtus, Anne, Vinckx, Joseph, de Zegher, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001293/
https://www.ncbi.nlm.nih.gov/pubmed/32042280
http://dx.doi.org/10.1186/s13633-020-0074-9
_version_ 1783494212224811008
author Rochtus, Anne
Vinckx, Joseph
de Zegher, Francis
author_facet Rochtus, Anne
Vinckx, Joseph
de Zegher, Francis
author_sort Rochtus, Anne
collection PubMed
description BACKGROUND: Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. CASE PRESENTATION: A 7-year-old boy was referred for short stature and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth. CONCLUSIONS: The present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored.
format Online
Article
Text
id pubmed-7001293
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-70012932020-02-10 Hypothalamic lipoma and growth hormone deficiency Rochtus, Anne Vinckx, Joseph de Zegher, Francis Int J Pediatr Endocrinol Case Report BACKGROUND: Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. CASE PRESENTATION: A 7-year-old boy was referred for short stature and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth. CONCLUSIONS: The present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored. BioMed Central 2020-02-05 2020 /pmc/articles/PMC7001293/ /pubmed/32042280 http://dx.doi.org/10.1186/s13633-020-0074-9 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Rochtus, Anne
Vinckx, Joseph
de Zegher, Francis
Hypothalamic lipoma and growth hormone deficiency
title Hypothalamic lipoma and growth hormone deficiency
title_full Hypothalamic lipoma and growth hormone deficiency
title_fullStr Hypothalamic lipoma and growth hormone deficiency
title_full_unstemmed Hypothalamic lipoma and growth hormone deficiency
title_short Hypothalamic lipoma and growth hormone deficiency
title_sort hypothalamic lipoma and growth hormone deficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001293/
https://www.ncbi.nlm.nih.gov/pubmed/32042280
http://dx.doi.org/10.1186/s13633-020-0074-9
work_keys_str_mv AT rochtusanne hypothalamiclipomaandgrowthhormonedeficiency
AT vinckxjoseph hypothalamiclipomaandgrowthhormonedeficiency
AT dezegherfrancis hypothalamiclipomaandgrowthhormonedeficiency

Ejemplares similares