SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability

SMC5/6 function in genome integrity remains elusive. Here, we show that SMC5 dysfunction in avian DT40 B cells causes mitotic delay and hypersensitivity toward DNA intra‐ and inter‐strand crosslinkers (ICLs), with smc5 mutants being epistatic to FANCC and FANCM mutations affecting the Fanconi anemia...

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Detalles Bibliográficos
Autores principales: Rossi, Francesco, Helbling‐Leclerc, Anne, Kawasumi, Ryotaro, Jegadesan, Nanda Kumar, Xu, Xinlin, Devulder, Pierre, Abe, Takuya, Takata, Minoru, Xu, Dongyi, Rosselli, Filippo, Branzei, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001510/
https://www.ncbi.nlm.nih.gov/pubmed/31867888
http://dx.doi.org/10.15252/embr.201948222

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