Heme oxygenase‐1 deficiency triggers exhaustion of hematopoietic stem cells

While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche—endothelial cells (ECs) and CXCL12‐abundant reticular cells (CARs)—highly express the heme‐degrading enzyme...

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Detalles Bibliográficos
Autores principales: Szade, Krzysztof, Zukowska, Monika, Szade, Agata, Nowak, Witold, Skulimowska, Izabella, Ciesla, Maciej, Bukowska‐Strakova, Karolina, Gulati, Gunsagar Singh, Kachamakova‐Trojanowska, Neli, Kusienicka, Anna, Einwallner, Elisa, Kijowski, Jacek, Czauderna, Szymon, Esterbauer, Harald, Benes, Vladimir, L Weissman, Irving, Dulak, Jozef, Jozkowicz, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001511/
https://www.ncbi.nlm.nih.gov/pubmed/31885181
http://dx.doi.org/10.15252/embr.201947895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001511/
https://www.ncbi.nlm.nih.gov/pubmed/31885181
http://dx.doi.org/10.15252/embr.201947895

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