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Promoter hypermethylation of the AE2/SLC4A2 gene in PBC

BACKGROUND & AIMS: Patients with primary biliary cholangitis (PBC) exhibit reduced AE2/SLC4A2 gene expression in the liver and peripheral blood mononuclear cells (PBMCs). AE2 encodes a Cl(–)/HCO(3)(–) exchanger involved in biliary bicarbonate secretion and intracellular pH regulation. Reduced AE...

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Detalles Bibliográficos
Autores principales:	Arenas, Fabián, Hervías, Isabel, Sáez, Elena, Melero, Saida, Prieto, Jesús, Parés, Albert, Medina, Juan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001545/ https://www.ncbi.nlm.nih.gov/pubmed/32039364 http://dx.doi.org/10.1016/j.jhepr.2019.05.006

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