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Opioid epidemic and liver disease
Opioid use in the United States and in many parts of the world has reached epidemic proportions. This has led to excess mortality as well as significant changes in the epidemiology of liver disease. Herein, we review the impact of the opioid epidemic on liver disease, focusing on the multifaceted im...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001546/ https://www.ncbi.nlm.nih.gov/pubmed/32039374 http://dx.doi.org/10.1016/j.jhepr.2019.06.006 |
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author | Verna, Elizabeth C. Schluger, Aaron Brown, Robert S. |
author_facet | Verna, Elizabeth C. Schluger, Aaron Brown, Robert S. |
author_sort | Verna, Elizabeth C. |
collection | PubMed |
description | Opioid use in the United States and in many parts of the world has reached epidemic proportions. This has led to excess mortality as well as significant changes in the epidemiology of liver disease. Herein, we review the impact of the opioid epidemic on liver disease, focusing on the multifaceted impact this epidemic has had on liver disease and liver transplantation. In particular, the opioid crisis has led to a significant shift in incident hepatitis C virus infection to younger populations and to women, leading to changes in screening recommendations. Less well characterized are the potential direct and indirect hepatotoxic effects of opioids, as well as the changes in the incidence of hepatitis B virus infection and alcohol abuse that are likely rising in this population as well. Finally, the opioid epidemic has led to a significant rise in the proportion of organ donors who died due to overdose. These donors have led to an overall increase in donor numbers, but also to new considerations about the better use of donors with perceived or actual risk of disease transmission, especially hepatitis C. Clearly, additional efforts are needed to combat the opioid epidemic. Moreover, better understanding of the epidemiology and underlying pathophysiology will help to identify and treat liver disease in this high-risk population. |
format | Online Article Text |
id | pubmed-7001546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70015462020-02-07 Opioid epidemic and liver disease Verna, Elizabeth C. Schluger, Aaron Brown, Robert S. JHEP Rep Review Opioid use in the United States and in many parts of the world has reached epidemic proportions. This has led to excess mortality as well as significant changes in the epidemiology of liver disease. Herein, we review the impact of the opioid epidemic on liver disease, focusing on the multifaceted impact this epidemic has had on liver disease and liver transplantation. In particular, the opioid crisis has led to a significant shift in incident hepatitis C virus infection to younger populations and to women, leading to changes in screening recommendations. Less well characterized are the potential direct and indirect hepatotoxic effects of opioids, as well as the changes in the incidence of hepatitis B virus infection and alcohol abuse that are likely rising in this population as well. Finally, the opioid epidemic has led to a significant rise in the proportion of organ donors who died due to overdose. These donors have led to an overall increase in donor numbers, but also to new considerations about the better use of donors with perceived or actual risk of disease transmission, especially hepatitis C. Clearly, additional efforts are needed to combat the opioid epidemic. Moreover, better understanding of the epidemiology and underlying pathophysiology will help to identify and treat liver disease in this high-risk population. Elsevier 2019-07-09 /pmc/articles/PMC7001546/ /pubmed/32039374 http://dx.doi.org/10.1016/j.jhepr.2019.06.006 Text en © 2019 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Verna, Elizabeth C. Schluger, Aaron Brown, Robert S. Opioid epidemic and liver disease |
title | Opioid epidemic and liver disease |
title_full | Opioid epidemic and liver disease |
title_fullStr | Opioid epidemic and liver disease |
title_full_unstemmed | Opioid epidemic and liver disease |
title_short | Opioid epidemic and liver disease |
title_sort | opioid epidemic and liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001546/ https://www.ncbi.nlm.nih.gov/pubmed/32039374 http://dx.doi.org/10.1016/j.jhepr.2019.06.006 |
work_keys_str_mv | AT vernaelizabethc opioidepidemicandliverdisease AT schlugeraaron opioidepidemicandliverdisease AT brownroberts opioidepidemicandliverdisease |