Cargando…

In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice

BACKGROUND: Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this...

Descripción completa

Detalles Bibliográficos
Autores principales: Biruk, Hana, Sentayehu, Biruk, Alebachew, Yonatan, Tamiru, Wondmagegn, Ejigu, Abebe, Assefa, Solomon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001668/
https://www.ncbi.nlm.nih.gov/pubmed/32047669
http://dx.doi.org/10.1155/2020/9749410
_version_ 1783494286027784192
author Biruk, Hana
Sentayehu, Biruk
Alebachew, Yonatan
Tamiru, Wondmagegn
Ejigu, Abebe
Assefa, Solomon
author_facet Biruk, Hana
Sentayehu, Biruk
Alebachew, Yonatan
Tamiru, Wondmagegn
Ejigu, Abebe
Assefa, Solomon
author_sort Biruk, Hana
collection PubMed
description BACKGROUND: Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of Terminalia brownii in Plasmodium berghei infected mice. METHODS: A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of T. brownii against P. berghei in Swiss albino mice. RESULTS: The in vivo acute toxicity test indicated that both extracts of T. brownii against p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant ( CONCLUSION: The present study indicated that hydromethanolic and aqueous bark extracts of T. brownii possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract.T. brownii against
format Online
Article
Text
id pubmed-7001668
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-70016682020-02-11 In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice Biruk, Hana Sentayehu, Biruk Alebachew, Yonatan Tamiru, Wondmagegn Ejigu, Abebe Assefa, Solomon Biochem Res Int Research Article BACKGROUND: Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of Terminalia brownii in Plasmodium berghei infected mice. METHODS: A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of T. brownii against P. berghei in Swiss albino mice. RESULTS: The in vivo acute toxicity test indicated that both extracts of T. brownii against p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant ( CONCLUSION: The present study indicated that hydromethanolic and aqueous bark extracts of T. brownii possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract.T. brownii against Hindawi 2020-01-22 /pmc/articles/PMC7001668/ /pubmed/32047669 http://dx.doi.org/10.1155/2020/9749410 Text en Copyright © 2020 Hana Biruk et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Biruk, Hana
Sentayehu, Biruk
Alebachew, Yonatan
Tamiru, Wondmagegn
Ejigu, Abebe
Assefa, Solomon
In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
title In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
title_full In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
title_fullStr In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
title_full_unstemmed In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
title_short In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
title_sort in vivo antimalarial activity of 80% methanol and aqueous bark extracts of terminalia brownii fresen. (combretaceae) against plasmodium berghei in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001668/
https://www.ncbi.nlm.nih.gov/pubmed/32047669
http://dx.doi.org/10.1155/2020/9749410
work_keys_str_mv AT birukhana invivoantimalarialactivityof80methanolandaqueousbarkextractsofterminaliabrowniifresencombretaceaeagainstplasmodiumbergheiinmice
AT sentayehubiruk invivoantimalarialactivityof80methanolandaqueousbarkextractsofterminaliabrowniifresencombretaceaeagainstplasmodiumbergheiinmice
AT alebachewyonatan invivoantimalarialactivityof80methanolandaqueousbarkextractsofterminaliabrowniifresencombretaceaeagainstplasmodiumbergheiinmice
AT tamiruwondmagegn invivoantimalarialactivityof80methanolandaqueousbarkextractsofterminaliabrowniifresencombretaceaeagainstplasmodiumbergheiinmice
AT ejiguabebe invivoantimalarialactivityof80methanolandaqueousbarkextractsofterminaliabrowniifresencombretaceaeagainstplasmodiumbergheiinmice
AT assefasolomon invivoantimalarialactivityof80methanolandaqueousbarkextractsofterminaliabrowniifresencombretaceaeagainstplasmodiumbergheiinmice