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The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning
OBJECTIVE: Mushroom poisonings can lead to life-threatening organ dysfunctions and neurotoxicity-related encephalopathy. This study aimed to detect increased intracranial pressure by measuring optic nerve sheath diameter (ONSD) ultrasonographically and to determine its association with clinical and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Turkish Anaesthesiology and Intensive Care Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001805/ https://www.ncbi.nlm.nih.gov/pubmed/32076682 http://dx.doi.org/10.5152/TJAR.2019.37891 |
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author | Gül, Fethi Sayan, İsmet Arıkan, Hüseyin Karacabey, Sinan Arslantaş, Mustafa Kemal Cinel, İsmail |
author_facet | Gül, Fethi Sayan, İsmet Arıkan, Hüseyin Karacabey, Sinan Arslantaş, Mustafa Kemal Cinel, İsmail |
author_sort | Gül, Fethi |
collection | PubMed |
description | OBJECTIVE: Mushroom poisonings can lead to life-threatening organ dysfunctions and neurotoxicity-related encephalopathy. This study aimed to detect increased intracranial pressure by measuring optic nerve sheath diameter (ONSD) ultrasonographically and to determine its association with clinical and laboratory parameters. METHODS: In this prospective case-control study, we evaluated the patients aged above 18 years who presented to the emergency department with mushroom poisoning. Vital signs, clinical and laboratory parameters and ONSD of both eyes measured with transocular ultrasound were noted at initial admission and the 24th hour. RESULTS: We measured ONSD in 26 cases with mushroom poisoning and 26 healthy volunteers. Baseline ONSD measurements of the poisoning group were significantly higher than those of the control group (5.94±0.73 vs. 4.11±0.64, p<0.0001). ONSD values significantly regressed at 24th hour compared with the baseline measurements in the poisoning group (5.94±0.73 vs. 5.06±0.56, p<0.001).The ONSD values were significantly higher in patients who had a clinical picture of encephalopathy compared with patients who didn’t have (6.05±0.72 vs. 4.36±1.03, p<0.001). No significant deterioration was observed in ammonium levels, hepatic and renal functions of the patients. CONCLUSION: We detected increased ONSDs in patients with mushroom poisoning compared with those in the control healthy volunteers. Our findings suggest that ONSD, measured by ultrasonography, may be safely and effectively used to diagnose transient encephalopathy associated with neurotoxicity. |
format | Online Article Text |
id | pubmed-7001805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Turkish Anaesthesiology and Intensive Care Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-70018052020-02-19 The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning Gül, Fethi Sayan, İsmet Arıkan, Hüseyin Karacabey, Sinan Arslantaş, Mustafa Kemal Cinel, İsmail Turk J Anaesthesiol Reanim Original Article OBJECTIVE: Mushroom poisonings can lead to life-threatening organ dysfunctions and neurotoxicity-related encephalopathy. This study aimed to detect increased intracranial pressure by measuring optic nerve sheath diameter (ONSD) ultrasonographically and to determine its association with clinical and laboratory parameters. METHODS: In this prospective case-control study, we evaluated the patients aged above 18 years who presented to the emergency department with mushroom poisoning. Vital signs, clinical and laboratory parameters and ONSD of both eyes measured with transocular ultrasound were noted at initial admission and the 24th hour. RESULTS: We measured ONSD in 26 cases with mushroom poisoning and 26 healthy volunteers. Baseline ONSD measurements of the poisoning group were significantly higher than those of the control group (5.94±0.73 vs. 4.11±0.64, p<0.0001). ONSD values significantly regressed at 24th hour compared with the baseline measurements in the poisoning group (5.94±0.73 vs. 5.06±0.56, p<0.001).The ONSD values were significantly higher in patients who had a clinical picture of encephalopathy compared with patients who didn’t have (6.05±0.72 vs. 4.36±1.03, p<0.001). No significant deterioration was observed in ammonium levels, hepatic and renal functions of the patients. CONCLUSION: We detected increased ONSDs in patients with mushroom poisoning compared with those in the control healthy volunteers. Our findings suggest that ONSD, measured by ultrasonography, may be safely and effectively used to diagnose transient encephalopathy associated with neurotoxicity. Turkish Anaesthesiology and Intensive Care Society 2020-02 2019-10-08 /pmc/articles/PMC7001805/ /pubmed/32076682 http://dx.doi.org/10.5152/TJAR.2019.37891 Text en © Copyright 2020 by Turkish Anaesthesiology and Intensive Care Society This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Original Article Gül, Fethi Sayan, İsmet Arıkan, Hüseyin Karacabey, Sinan Arslantaş, Mustafa Kemal Cinel, İsmail The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning |
title | The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning |
title_full | The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning |
title_fullStr | The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning |
title_full_unstemmed | The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning |
title_short | The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning |
title_sort | role of transocular ultrasound in the assessment of neurotoxicity-related encephalopathy in mushroom poisoning |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001805/ https://www.ncbi.nlm.nih.gov/pubmed/32076682 http://dx.doi.org/10.5152/TJAR.2019.37891 |
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