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Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001879/ https://www.ncbi.nlm.nih.gov/pubmed/30784583 http://dx.doi.org/10.1016/j.celrep.2019.01.093 |
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author | Lacefield, Clay O. Pnevmatikakis, Eftychios A. Paninski, Liam Bruno, Randy M. |
author_facet | Lacefield, Clay O. Pnevmatikakis, Eftychios A. Paninski, Liam Bruno, Randy M. |
author_sort | Lacefield, Clay O. |
collection | PubMed |
description | The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-level representations. Here, we imaged layer 1 apical dendrites in the barrel cortex of mice performing a whisker-based operant behavior. In addition to sensory-motor events, calcium signals in apical dendrites of layers 2/3 and 5 neurons and in layer 2/3 somata track the delivery of rewards, both choice related and randomly administered. Reward-related tuft-wide dendritic spikes emerge gradually with training and are task specific. Learning recruits cells whose intrinsic activity coincides with the time of reinforcement. Layer 4 largely lacked reward-related signals, suggesting a source other than the primary thalamus. Our results demonstrate that a sensory cortex can acquire a set of associations outside its immediate sensory modality and linked to salient behavioral events. |
format | Online Article Text |
id | pubmed-7001879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-70018792020-02-05 Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex Lacefield, Clay O. Pnevmatikakis, Eftychios A. Paninski, Liam Bruno, Randy M. Cell Rep Article The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-level representations. Here, we imaged layer 1 apical dendrites in the barrel cortex of mice performing a whisker-based operant behavior. In addition to sensory-motor events, calcium signals in apical dendrites of layers 2/3 and 5 neurons and in layer 2/3 somata track the delivery of rewards, both choice related and randomly administered. Reward-related tuft-wide dendritic spikes emerge gradually with training and are task specific. Learning recruits cells whose intrinsic activity coincides with the time of reinforcement. Layer 4 largely lacked reward-related signals, suggesting a source other than the primary thalamus. Our results demonstrate that a sensory cortex can acquire a set of associations outside its immediate sensory modality and linked to salient behavioral events. 2019-02-19 /pmc/articles/PMC7001879/ /pubmed/30784583 http://dx.doi.org/10.1016/j.celrep.2019.01.093 Text en This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lacefield, Clay O. Pnevmatikakis, Eftychios A. Paninski, Liam Bruno, Randy M. Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex |
title | Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex |
title_full | Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex |
title_fullStr | Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex |
title_full_unstemmed | Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex |
title_short | Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex |
title_sort | reinforcement learning recruits somata and apical dendrites across layers of primary sensory cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001879/ https://www.ncbi.nlm.nih.gov/pubmed/30784583 http://dx.doi.org/10.1016/j.celrep.2019.01.093 |
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