Cargando…

Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex

The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacefield, Clay O., Pnevmatikakis, Eftychios A., Paninski, Liam, Bruno, Randy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001879/
https://www.ncbi.nlm.nih.gov/pubmed/30784583
http://dx.doi.org/10.1016/j.celrep.2019.01.093
_version_ 1783494304751157248
author Lacefield, Clay O.
Pnevmatikakis, Eftychios A.
Paninski, Liam
Bruno, Randy M.
author_facet Lacefield, Clay O.
Pnevmatikakis, Eftychios A.
Paninski, Liam
Bruno, Randy M.
author_sort Lacefield, Clay O.
collection PubMed
description The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-level representations. Here, we imaged layer 1 apical dendrites in the barrel cortex of mice performing a whisker-based operant behavior. In addition to sensory-motor events, calcium signals in apical dendrites of layers 2/3 and 5 neurons and in layer 2/3 somata track the delivery of rewards, both choice related and randomly administered. Reward-related tuft-wide dendritic spikes emerge gradually with training and are task specific. Learning recruits cells whose intrinsic activity coincides with the time of reinforcement. Layer 4 largely lacked reward-related signals, suggesting a source other than the primary thalamus. Our results demonstrate that a sensory cortex can acquire a set of associations outside its immediate sensory modality and linked to salient behavioral events.
format Online
Article
Text
id pubmed-7001879
institution National Center for Biotechnology Information
language English
publishDate 2019
record_format MEDLINE/PubMed
spelling pubmed-70018792020-02-05 Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex Lacefield, Clay O. Pnevmatikakis, Eftychios A. Paninski, Liam Bruno, Randy M. Cell Rep Article The mammalian brain can form associations between behaviorally relevant stimuli in an animal’s environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-level representations. Here, we imaged layer 1 apical dendrites in the barrel cortex of mice performing a whisker-based operant behavior. In addition to sensory-motor events, calcium signals in apical dendrites of layers 2/3 and 5 neurons and in layer 2/3 somata track the delivery of rewards, both choice related and randomly administered. Reward-related tuft-wide dendritic spikes emerge gradually with training and are task specific. Learning recruits cells whose intrinsic activity coincides with the time of reinforcement. Layer 4 largely lacked reward-related signals, suggesting a source other than the primary thalamus. Our results demonstrate that a sensory cortex can acquire a set of associations outside its immediate sensory modality and linked to salient behavioral events. 2019-02-19 /pmc/articles/PMC7001879/ /pubmed/30784583 http://dx.doi.org/10.1016/j.celrep.2019.01.093 Text en This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lacefield, Clay O.
Pnevmatikakis, Eftychios A.
Paninski, Liam
Bruno, Randy M.
Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
title Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
title_full Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
title_fullStr Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
title_full_unstemmed Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
title_short Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex
title_sort reinforcement learning recruits somata and apical dendrites across layers of primary sensory cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001879/
https://www.ncbi.nlm.nih.gov/pubmed/30784583
http://dx.doi.org/10.1016/j.celrep.2019.01.093
work_keys_str_mv AT lacefieldclayo reinforcementlearningrecruitssomataandapicaldendritesacrosslayersofprimarysensorycortex
AT pnevmatikakiseftychiosa reinforcementlearningrecruitssomataandapicaldendritesacrosslayersofprimarysensorycortex
AT paninskiliam reinforcementlearningrecruitssomataandapicaldendritesacrosslayersofprimarysensorycortex
AT brunorandym reinforcementlearningrecruitssomataandapicaldendritesacrosslayersofprimarysensorycortex