Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas scaffold-mediated positive feedback was proposed to break symmetry of budding yeast cells and produce a single zone of Cdc42 activity, the existence of similar regulation has not been probed in other organisms. Here,...

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Detalles Bibliográficos
Autores principales: Lamas, Iker, Merlini, Laura, Vještica, Aleksandar, Vincenzetti, Vincent, Martin, Sophie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002011/
https://www.ncbi.nlm.nih.gov/pubmed/31978045
http://dx.doi.org/10.1371/journal.pbio.3000600

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