Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells

Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), particularly in NOTCH1-mutated patients. We provide first evidence that the Notch ligand DLL4 is a potent stimulator of Notch signaling in NOTCH1-mutated CLL cells while increases cell p...

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Detalles Bibliográficos
Autores principales: López-Guerra, Mónica, Xargay-Torrent, Sílvia, Fuentes, Patricia, Roldán, Jocabed, González-Farré, Blanca, Rosich, Laia, Silkenstedt, Elisabeth, García-León, María J., Lee-Vergés, Eriong, Giménez, Neus, Giró, Ariadna, Aymerich, Marta, Villamor, Neus, Delgado, Julio, López-Guillermo, Armando, Puente, Xose S., Campo, Elias, Toribio, María L., Colomer, Dolors
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002297/
https://www.ncbi.nlm.nih.gov/pubmed/31616059
http://dx.doi.org/10.1038/s41388-019-1053-6

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