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17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells

Plasma levels of PCSK9 are significantly higher in postmenopausal women. Pharmacologically increased estrogen levels have been shown to lower PCSK9 and LDL-C levels in animals and humans. The action of estrogen suggests that it has the ability to prevent PCSK9-mediated LDLR degradation in liver cell...

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Detalles Bibliográficos
Autores principales:	Fu, Wei, Gao, Xiao-Ping, Zhang, Sheng, Dai, Yan-Ping, Zou, Wen-Jun, Yue, Li-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002320/ https://www.ncbi.nlm.nih.gov/pubmed/32082252 http://dx.doi.org/10.3389/fendo.2019.00930

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