Cargando…

17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells

Plasma levels of PCSK9 are significantly higher in postmenopausal women. Pharmacologically increased estrogen levels have been shown to lower PCSK9 and LDL-C levels in animals and humans. The action of estrogen suggests that it has the ability to prevent PCSK9-mediated LDLR degradation in liver cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Wei, Gao, Xiao-Ping, Zhang, Sheng, Dai, Yan-Ping, Zou, Wen-Jun, Yue, Li-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002320/ https://www.ncbi.nlm.nih.gov/pubmed/32082252 http://dx.doi.org/10.3389/fendo.2019.00930

Ejemplares similares

Allicin and Capsaicin Ameliorated Hypercholesterolemia by Upregulating LDLR and Downregulating PCSK9 Expression in HepG2 Cells
por: Nawaka, Nantiya, et al.
Publicado: (2022)

An Untargeted Metabolomics Approach to Investigate the Metabolic Modulations of HepG2 Cells Exposed to Low Doses of Bisphenol A and 17β-Estradiol
por: Cabaton, Nicolas J., et al.
Publicado: (2018)

PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells
por: Lagace, Thomas A.
Publicado: (2014)

PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation
por: Luna Saavedra, Yascara Grisel, et al.
Publicado: (2013)

The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells
por: Chang, Heng-Yuan, et al.
Publicado: (2019)

Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain
por: Poirier, Steve, et al.
Publicado: (2016)

Impact of Soy β-Conglycinin Peptides on PCSK9 Protein Expression in HepG2 Cells
por: Macchi, Chiara, et al.
Publicado: (2021)

17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway
por: Bian, Che, et al.
Publicado: (2019)

The effect of PCSK9 immunization on the hepatic level of microRNAs associated with the PCSK9/LDLR pathway
por: Ataei, Sarina, et al.
Publicado: (2023)

PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis
por: Arida, Aikaterini, et al.
Publicado: (2021)

Female Heart Health: Is GPER the Missing Link?
por: Groban, Leanne, et al.
Publicado: (2020)

Effect of Genistein and 17-β Estradiol on the Viability and Apoptosis of Human Hepatocellular Carcinoma HepG2 cell line
por: Sanaei, Masumeh, et al.
Publicado: (2017)

Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells
por: Lammi, Carmen, et al.
Publicado: (2016)

Editorial: GPER and Human Pathologies
por: Jacquot, Yves, et al.
Publicado: (2021)

Editorial: GPER: Control and Functions
por: Jacquot, Yves, et al.
Publicado: (2021)

The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia
por: Meshkov, Alexey, et al.
Publicado: (2021)

Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF-κB signaling
por: Ma, Baitao, et al.
Publicado: (2021)

c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway
por: Xu, Weiming, et al.
Publicado: (2012)

GPER Signaling in Spermatogenesis and Testicular Tumors
por: Chimento, Adele, et al.
Publicado: (2014)

GPER Function in Breast Cancer: An Overview
por: Lappano, Rosamaria, et al.
Publicado: (2014)

GPER and Testicular Germ Cell Cancer
por: Chevalier, Nicolas, et al.
Publicado: (2021)

17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation
por: Guo, Yusheng, et al.
Publicado: (2021)

Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells
por: Shen, Minqian, et al.
Publicado: (2016)

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells
por: Chen, Hung-Chen, et al.
Publicado: (2016)

Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells
por: Masagalli, Jagadeesh Nagarajappa, et al.
Publicado: (2021)

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR
por: Safarova, Maya S., et al.
Publicado: (2019)

In Silico Insights into Protein–Protein Interaction Disruptive Mutations in the PCSK9-LDLR Complex
por: Martin, William R., et al.
Publicado: (2020)

Computational Approaches for the Discovery of GPER Targeting Compounds
por: Grande, Fedora, et al.
Publicado: (2020)

The Dipeptide Pro-Gly Promotes IGF-1 Expression and Secretion in HepG2 and Female Mice via PepT1-JAK2/STAT5 Pathway
por: Zhang, Mengyuan, et al.
Publicado: (2018)

Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function
por: Rouhimoghadam, Milad, et al.
Publicado: (2020)

Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia
por: Ježek, Jan, et al.
Publicado: (2018)

6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells
por: Li, Xiao, et al.
Publicado: (2018)

The Antitumor Peptide ERα17p Exerts Anti-Hyperalgesic and Anti-Inflammatory Actions Through GPER in Mice
por: Mallet, Christophe, et al.
Publicado: (2021)

Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats
por: Duarte-Guterman, Paula, et al.
Publicado: (2015)

The Cholesterol-Modulating Effect of the New Herbal Medicinal Recipe from Yellow Vine (Coscinium fenestratum (Goetgh.)), Ginger (Zingiber officinale Roscoe.), and Safflower (Carthamus tinctorius L.) on Suppressing PCSK9 Expression to Upregulate LDLR Expression in HepG2 Cells
por: Ongtanasup, Tassanee, et al.
Publicado: (2022)

GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs)
por: Périan, Séverine, et al.
Publicado: (2020)

Reduced Vitellogenesis and Female Fertility in Gper Knockout Zebrafish
por: Wu, Xin-Jun, et al.
Publicado: (2021)

Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations
por: Futema, Marta, et al.
Publicado: (2014)

LDLR and PCSK9 Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA Carriers
por: Ochoa, Eguzkine, et al.
Publicado: (2016)

Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo?
por: Luo, Jing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_63jjvogijp0ekfgs5erpcr30an