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Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach
Deciphering the evolutionary history of pathogenic bacteria and their near neighbors may help to understand the genetic or ecological bases which led to their pathogenic behavior. The Brucellaceae family comprises zoonotic pathogenic species belonging to the genus Brucella as well as the environment...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002325/ https://www.ncbi.nlm.nih.gov/pubmed/32082266 http://dx.doi.org/10.3389/fmicb.2019.03083 |
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author | Leclercq, Sébastien O. Cloeckaert, Axel Zygmunt, Michel S. |
author_facet | Leclercq, Sébastien O. Cloeckaert, Axel Zygmunt, Michel S. |
author_sort | Leclercq, Sébastien O. |
collection | PubMed |
description | Deciphering the evolutionary history of pathogenic bacteria and their near neighbors may help to understand the genetic or ecological bases which led to their pathogenic behavior. The Brucellaceae family comprises zoonotic pathogenic species belonging to the genus Brucella as well as the environmental genus Ochrobactrum for which some species are considered as opportunistic pathogens. Here, we used a phylogenomic approach including a set of 145 Brucellaceae genomes representative of the family diversity and more than 40 genomes of the order Rhizobiales to infer the taxonomic relationships between the family’s species. Our results clarified some unresolved phylogenetic ambiguities, conducting to the exclusion of Mycoplana spp. out of the family Brucellaceae and the positioning of all Brucella spp. as a single genomic species within the current Ochrobactrum species diversity. Additional analyses also revealed that Ochrobactrum spp. separate into two clades, one comprising mostly environmental species while the other one includes the species considered as pathogens (Brucella spp.) or opportunistic pathogens (mainly O. anthropi, O. intermedium, and O. pseudintermedium). Finally, we show that O. intermedium is undergoing a beginning of genome reduction suggestive of an ongoing ecological niche specialization, and that some lineages of O. intermedium and O. anthropi may shift toward an adaption to the human host. |
format | Online Article Text |
id | pubmed-7002325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70023252020-02-20 Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach Leclercq, Sébastien O. Cloeckaert, Axel Zygmunt, Michel S. Front Microbiol Microbiology Deciphering the evolutionary history of pathogenic bacteria and their near neighbors may help to understand the genetic or ecological bases which led to their pathogenic behavior. The Brucellaceae family comprises zoonotic pathogenic species belonging to the genus Brucella as well as the environmental genus Ochrobactrum for which some species are considered as opportunistic pathogens. Here, we used a phylogenomic approach including a set of 145 Brucellaceae genomes representative of the family diversity and more than 40 genomes of the order Rhizobiales to infer the taxonomic relationships between the family’s species. Our results clarified some unresolved phylogenetic ambiguities, conducting to the exclusion of Mycoplana spp. out of the family Brucellaceae and the positioning of all Brucella spp. as a single genomic species within the current Ochrobactrum species diversity. Additional analyses also revealed that Ochrobactrum spp. separate into two clades, one comprising mostly environmental species while the other one includes the species considered as pathogens (Brucella spp.) or opportunistic pathogens (mainly O. anthropi, O. intermedium, and O. pseudintermedium). Finally, we show that O. intermedium is undergoing a beginning of genome reduction suggestive of an ongoing ecological niche specialization, and that some lineages of O. intermedium and O. anthropi may shift toward an adaption to the human host. Frontiers Media S.A. 2020-01-30 /pmc/articles/PMC7002325/ /pubmed/32082266 http://dx.doi.org/10.3389/fmicb.2019.03083 Text en Copyright © 2020 Leclercq, Cloeckaert and Zygmunt. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Leclercq, Sébastien O. Cloeckaert, Axel Zygmunt, Michel S. Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach |
title | Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach |
title_full | Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach |
title_fullStr | Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach |
title_full_unstemmed | Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach |
title_short | Taxonomic Organization of the Family Brucellaceae Based on a Phylogenomic Approach |
title_sort | taxonomic organization of the family brucellaceae based on a phylogenomic approach |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002325/ https://www.ncbi.nlm.nih.gov/pubmed/32082266 http://dx.doi.org/10.3389/fmicb.2019.03083 |
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