Cargando…

The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils

The cag type IV secretion system (cag-T4SS) of Helicobacter pylori exploits specific cellular carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), such as CEACAM1, -3, -5, and -6, as cellular receptors for CagA translocation into human gastric epithelial cells. We studied the interact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Behrens, Ina-Kristin, Busch, Benjamin, Ishikawa-Ankerhold, Hellen, Palamides, Pia, Shively, John E., Stanners, Cliff, Chan, Carlos, Leung, Nelly, Gray-Owen, Scott, Haas, Rainer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002351/ https://www.ncbi.nlm.nih.gov/pubmed/32019805 http://dx.doi.org/10.1128/mBio.03256-19

Ejemplares similares

Cysteine Residues in Helicobacter pylori Adhesin HopQ Are Required for CEACAM–HopQ Interaction and Subsequent CagA Translocation
por: Hamway, Youssef, et al.
Publicado: (2020)

Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation
por: Zhao, Qing, et al.
Publicado: (2018)

Effects of Helicobacter pylori adhesin HopQ binding to CEACAM receptors in the human stomach
por: Nguyen, Quynh Anh, et al.
Publicado: (2023)

Engagement of CEACAM1 by Helicobacter pylori HopQ Is Important for the Activation of Non-Canonical NF-κB in Gastric Epithelial Cells
por: Taxauer, Karin, et al.
Publicado: (2021)

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer
por: Roy, Rony K., et al.
Publicado: (2016)

Pathogenic interactions between Helicobacter pylori adhesion protein HopQ and human cell surface adhesion molecules CEACAMs in gastric epithelial cells
por: Xia, Ran, et al.
Publicado: (2019)

Type IV secretion of Helicobacter pylori CagA into oral epithelial cells is prevented by the absence of CEACAM receptor expression
por: Tegtmeyer, Nicole, et al.
Publicado: (2020)

The CagA toxin of Helicobacter pylori: abundant production but relatively low amount translocated
por: Jiménez-Soto, Luisa F., et al.
Publicado: (2016)

Characterizing Helicobacter pylori cagA in Myanmar
por: Myint, Thein, et al.
Publicado: (2018)

Mixed Infection with cagA Positive and cagA Negative Strains of Helicobacter pylori Lowers Disease Burden in The Gambia
por: Secka, Ousman, et al.
Publicado: (2011)

CagA(+) Helicobacter pylori, Not CagA(–) Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation
por: Xia, Xiujuan, et al.
Publicado: (2022)

Difluoromethylornithine Is a Novel Inhibitor of Helicobacter pylori Growth, CagA Translocation, and Interleukin-8 Induction
por: Barry, Daniel P., et al.
Publicado: (2011)

High Prevalence of Helicobacter pylori hopQ II Genotype Isolated from Iranian Patients with Gastroduodenal Disorders
por: Talebi Bezmin Abadi, Amin, et al.
Publicado: (2014)

Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation
por: Wang, Ge, et al.
Publicado: (2016)

Evolution of cagA Oncogene of Helicobacter pylori through Recombination
por: Furuta, Yoshikazu, et al.
Publicado: (2011)

Conformational Analysis of Isolated Domains of Helicobacter pylori CagA
por: Woon, Amanda P., et al.
Publicado: (2013)

Preservation of Helicobacter pylori CagA Translocation and Host Cell Proinflammatory Responses in the Face of CagL Hypervariability at Amino Acid Residues 58/59
por: Tafreshi, Mona, et al.
Publicado: (2015)

Two Strategies of Pseudomonas syringae to Avoid Recognition of the HopQ1 Effector in Nicotiana Species
por: Zembek, Patrycja, et al.
Publicado: (2018)

Helicobacter pylori cagA gene variants in Malaysians of different ethnicity
por: Mohamed, Ramelah, et al.
Publicado: (2009)

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein
por: Suzuki, Nobumi, et al.
Publicado: (2015)

Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori
por: Su, Hanfu, et al.
Publicado: (2019)

Influence of Dietary Factors on Helicobacter pylori and CagA Seroprevalence in Bulgaria
por: Yordanov, Daniel, et al.
Publicado: (2017)

Construction, Cloning, and Expression of CagA Recombinant Protein of Helicobacter pylori
por: Shapouri Moghaddam, Abbas, et al.
Publicado: (2020)

An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA
por: Conradi, Jens, et al.
Publicado: (2012)

Immunostimulatory membrane proteins potentiate H. pylori-induced carcinogenesis by enabling CagA translocation
por: Varga, Matthew G., et al.
Publicado: (2020)

Novel Sensitive Electrochemical Immunosensor Development for the Selective Detection of HopQ H. pylori Bacteria Biomarker
por: Jaradat, Hussamaldeen, et al.
Publicado: (2023)

Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system
por: Blanc, Marine, et al.
Publicado: (2023)

Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA
por: Link, Alexander, et al.
Publicado: (2017)

Helicobacter pylori cagA+ Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients
por: Lucero, Yalda, et al.
Publicado: (2017)

Helicobacter pylori Infection in Thailand: A Nationwide Study of the CagA Phenotype
por: Uchida, Tomohisa, et al.
Publicado: (2015)

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA
por: Shimoda, Asako, et al.
Publicado: (2016)

Helicobacter pylori cagA and vacA genes in dyspeptic Ghanaian patients
por: Archampong, Timothy N., et al.
Publicado: (2017)

Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin
por: Park, Seung-Ho, et al.
Publicado: (2020)

Cag Type IV Secretion System: CagI Independent Bacterial Surface Localization of CagA
por: Kumar, Navin, et al.
Publicado: (2013)

Recent advances in the tumour biology of the GPI-anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6
por: Chan, C.H.F., et al.
Publicado: (2007)

Statins Attenuate Helicobacter pylori CagA Translocation and Reduce Incidence of Gastric Cancer: In Vitro and Population-Based Case-Control Studies
por: Lin, Chun-Jung, et al.
Publicado: (2016)

Role of CagA in H. pylori gastric cancer
Publicado: (2013)

EPIYA motiefs of cagA and upper gastrointestinal diseases
por: Soleiman-Meigooni, Saeed, et al.
Publicado: (2015)

Corrigendum: Helicobacter pylori cagA+ Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients
por: Lucero, Yalda, et al.
Publicado: (2017)

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori
por: Backert, Steffen, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_skr5brbdhp305b1oftvssf5pdr