Structure guided prediction of Pyrazinamide resistance mutations in pncA

Pyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing. Resistance to pyrazinamide is largely driven by mutations in pyrazinamidase (pncA), responsible for drug activation, but genetic h...

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Detalles Bibliográficos
Autores principales: Karmakar, Malancha, Rodrigues, Carlos H. M., Horan, Kristy, Denholm, Justin T., Ascher, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002382/
https://www.ncbi.nlm.nih.gov/pubmed/32024884
http://dx.doi.org/10.1038/s41598-020-58635-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002382/
https://www.ncbi.nlm.nih.gov/pubmed/32024884
http://dx.doi.org/10.1038/s41598-020-58635-x

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