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Clonal competition within complex evolutionary hierarchies shapes AML over time

Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing...

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Detalles Bibliográficos
Autores principales:	Sandén, Carl, Lilljebjörn, Henrik, Orsmark Pietras, Christina, Henningsson, Rasmus, Saba, Karim H., Landberg, Niklas, Thorsson, Hanna, von Palffy, Sofia, Peña-Martinez, Pablo, Högberg, Carl, Rissler, Marianne, Gisselsson, David, Lazarevic, Vladimir, Juliusson, Gunnar, Ågerstam, Helena, Fioretos, Thoas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002407/ https://www.ncbi.nlm.nih.gov/pubmed/32024830 http://dx.doi.org/10.1038/s41467-019-14106-0

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