Integrative network modeling reveals mechanisms underlying T cell exhaustion

Failure to clear antigens causes CD8(+) T cells to become increasingly hypo-functional, a state known as exhaustion. We combined manually extracted information from published literature with gene expression data from diverse model systems to infer a set of molecular regulatory interactions that unde...

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Detalles Bibliográficos
Autores principales: Bolouri, Hamid, Young, Mary, Beilke, Joshua, Johnson, Rebecca, Fox, Brian, Huang, Lu, Santini, Cristina Costa, Hill, Christopher Mark, Vries, Anne-Renee van der Vuurst de, Shannon, Paul T., Dervan, Andrew, Sivakumar, Pallavur, Trotter, Matthew, Bassett, Douglas, Ratushny, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002445/
https://www.ncbi.nlm.nih.gov/pubmed/32024856
http://dx.doi.org/10.1038/s41598-020-58600-8

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