Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of mature T cells associated with chronic infection by human T-cell lymphotropic virus type-1 (HTLV-1). ATLL patients with aggressive subtypes have dismal outcomes. We demonstrate that ATLL cells co-opt an early checkpoint within the tumor necros...

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Detalles Bibliográficos
Autores principales: Xu, Xin, Kalac, Matko, Markson, Michael, Chan, Mark, Brody, Joshua D., Bhagat, Govind, Ang, Rosalind L., Legarda, Diana, Justus, Scott J., Liu, Feng, Li, Qingshan, Xiong, Huabao, Ting, Adrian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002447/
https://www.ncbi.nlm.nih.gov/pubmed/32024820
http://dx.doi.org/10.1038/s41419-020-2294-6

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