STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia

We recently identified the CDC25A phosphatase as a key actor in proliferation and differentiation in acute myeloid leukemia expressing the FLT3-ITD mutation. In this paper we demonstrate that CDC25A level is controlled by a complex STAT5/miR-16 transcription and translation pathway working downstrea...

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Autores principales: Sueur, Gabrielle, Boutet, Alison, Gotanègre, Mathilde, Mansat-De Mas, Véronique, Besson, Arnaud, Manenti, Stéphane, Bertoli, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002454/
https://www.ncbi.nlm.nih.gov/pubmed/32024878
http://dx.doi.org/10.1038/s41598-020-58651-x

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