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Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment

Background: Amnestic mild cognitive impairment (aMCI) has a high conversion risk to Alzheimer’s disease (AD). The aMCI patients may have only a memory deficit (single-domain-aMCI, sd-aMCI) or deficits in multiple cognitive domains (multiple-domain-aMCI, md-aMCI). However, differences in intrinsic br...

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Autores principales: Zhou, Qi-Hui, Wang, Kun, Zhang, Xiao-Ming, Wang, Li, Liu, Jiang-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002564/
https://www.ncbi.nlm.nih.gov/pubmed/32082131
http://dx.doi.org/10.3389/fnhum.2020.00002
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author Zhou, Qi-Hui
Wang, Kun
Zhang, Xiao-Ming
Wang, Li
Liu, Jiang-Hong
author_facet Zhou, Qi-Hui
Wang, Kun
Zhang, Xiao-Ming
Wang, Li
Liu, Jiang-Hong
author_sort Zhou, Qi-Hui
collection PubMed
description Background: Amnestic mild cognitive impairment (aMCI) has a high conversion risk to Alzheimer’s disease (AD). The aMCI patients may have only a memory deficit (single-domain-aMCI, sd-aMCI) or deficits in multiple cognitive domains (multiple-domain-aMCI, md-aMCI). However, differences in intrinsic brain activity between these two sub-types remain unclear. Method: Neuropsychological and resting-state functional magnetic resonance imaging (fMRI) data were acquired from 24 patients with sd-aMCI, 23 patients with md-aMCI, and 32 healthy controls (HCs). We used the fractional amplitude of low-frequency fluctuation (fALFF) to characterize the intensity of spontaneous brain activity. The analysis of covariance (ANCOVA) and post hoc tests was performed to determine the between-group differences in fALFF. Results: We found higher fALFF in left-sided superior-to-middle frontal gyri and middle-to-inferior temporal gyri in sd-aMCI compared to both the md-aMCI and HCs. Conversely, a lower fALFF was found in the left inferior parietal lobe in both the md-aMCI and sd-aMCI patients. The fALFF values in the left middle and inferior temporal gyri were correlated with cognitive performances. Conclusion: The gradual reduction in the left inferior parietal lobe from single to multiple domain aMCI suggest a functional inefficiency underlying cognitive impairment, while increased activity in the frontal and temporal gyri in sd-aMCI rather than md-aMCI might indicate functional compensation. This study indicates differential functional profiles in the sd-aMCI and md-aMCI, which may be helpful for the prediction of the future conversion of aMCI to AD.
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spelling pubmed-70025642020-02-20 Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment Zhou, Qi-Hui Wang, Kun Zhang, Xiao-Ming Wang, Li Liu, Jiang-Hong Front Hum Neurosci Human Neuroscience Background: Amnestic mild cognitive impairment (aMCI) has a high conversion risk to Alzheimer’s disease (AD). The aMCI patients may have only a memory deficit (single-domain-aMCI, sd-aMCI) or deficits in multiple cognitive domains (multiple-domain-aMCI, md-aMCI). However, differences in intrinsic brain activity between these two sub-types remain unclear. Method: Neuropsychological and resting-state functional magnetic resonance imaging (fMRI) data were acquired from 24 patients with sd-aMCI, 23 patients with md-aMCI, and 32 healthy controls (HCs). We used the fractional amplitude of low-frequency fluctuation (fALFF) to characterize the intensity of spontaneous brain activity. The analysis of covariance (ANCOVA) and post hoc tests was performed to determine the between-group differences in fALFF. Results: We found higher fALFF in left-sided superior-to-middle frontal gyri and middle-to-inferior temporal gyri in sd-aMCI compared to both the md-aMCI and HCs. Conversely, a lower fALFF was found in the left inferior parietal lobe in both the md-aMCI and sd-aMCI patients. The fALFF values in the left middle and inferior temporal gyri were correlated with cognitive performances. Conclusion: The gradual reduction in the left inferior parietal lobe from single to multiple domain aMCI suggest a functional inefficiency underlying cognitive impairment, while increased activity in the frontal and temporal gyri in sd-aMCI rather than md-aMCI might indicate functional compensation. This study indicates differential functional profiles in the sd-aMCI and md-aMCI, which may be helpful for the prediction of the future conversion of aMCI to AD. Frontiers Media S.A. 2020-01-30 /pmc/articles/PMC7002564/ /pubmed/32082131 http://dx.doi.org/10.3389/fnhum.2020.00002 Text en Copyright © 2020 Zhou, Wang, Zhang, Wang and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Zhou, Qi-Hui
Wang, Kun
Zhang, Xiao-Ming
Wang, Li
Liu, Jiang-Hong
Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
title Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
title_full Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
title_fullStr Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
title_full_unstemmed Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
title_short Differential Regional Brain Spontaneous Activity in Subgroups of Mild Cognitive Impairment
title_sort differential regional brain spontaneous activity in subgroups of mild cognitive impairment
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002564/
https://www.ncbi.nlm.nih.gov/pubmed/32082131
http://dx.doi.org/10.3389/fnhum.2020.00002
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