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Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease

Bile acids are endogenous ligands of nuclear receptors pregnane X (PXR) and farnesoid X (FXR). PXR and FXR regulate pathways that are impaired in inflammatory bowel disease (IBD). Decreases in PXR and FXR activity are documented in IBD; however reasons for this are unknown. We aimed to assess the ef...

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Detalles Bibliográficos
Autores principales:	Wilson, Aze, Almousa, Ahmed, Teft, Wendy A., Kim, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002620/ https://www.ncbi.nlm.nih.gov/pubmed/32024859 http://dx.doi.org/10.1038/s41598-020-58644-w

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