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Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors, among which 4,6-d...

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Detalles Bibliográficos
Autores principales:	Schantl, Antonia E., Verhulst, Anja, Neven, Ellen, Behets, Geert J., D’Haese, Patrick C., Maillard, Marc, Mordasini, David, Phan, Olivier, Burnier, Michel, Spaggiari, Dany, Decosterd, Laurent A., MacAskill, Mark G., Alcaide-Corral, Carlos J., Tavares, Adriana A. S., Newby, David E., Beindl, Victoria C., Maj, Roberto, Labarre, Anne, Hegde, Chrismita, Castagner, Bastien, Ivarsson, Mattias E., Leroux, Jean-Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002685/ https://www.ncbi.nlm.nih.gov/pubmed/32024848 http://dx.doi.org/10.1038/s41467-019-14091-4

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