Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate

As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-u...

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Autores principales: Toyoda, Yu, Takada, Tappei, Saito, Hiroki, Hirata, Hiroshi, Ota-Kontani, Ami, Kobayashi, Naoyuki, Tsuchiya, Youichi, Suzuki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002704/
https://www.ncbi.nlm.nih.gov/pubmed/32047858
http://dx.doi.org/10.1038/s41538-020-0063-7
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author Toyoda, Yu
Takada, Tappei
Saito, Hiroki
Hirata, Hiroshi
Ota-Kontani, Ami
Kobayashi, Naoyuki
Tsuchiya, Youichi
Suzuki, Hiroshi
author_facet Toyoda, Yu
Takada, Tappei
Saito, Hiroki
Hirata, Hiroshi
Ota-Kontani, Ami
Kobayashi, Naoyuki
Tsuchiya, Youichi
Suzuki, Hiroshi
author_sort Toyoda, Yu
collection PubMed
description As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.
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spelling pubmed-70027042020-02-11 Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate Toyoda, Yu Takada, Tappei Saito, Hiroki Hirata, Hiroshi Ota-Kontani, Ami Kobayashi, Naoyuki Tsuchiya, Youichi Suzuki, Hiroshi NPJ Sci Food Brief Communication As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases. Nature Publishing Group UK 2020-02-05 /pmc/articles/PMC7002704/ /pubmed/32047858 http://dx.doi.org/10.1038/s41538-020-0063-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Toyoda, Yu
Takada, Tappei
Saito, Hiroki
Hirata, Hiroshi
Ota-Kontani, Ami
Kobayashi, Naoyuki
Tsuchiya, Youichi
Suzuki, Hiroshi
Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
title Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
title_full Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
title_fullStr Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
title_full_unstemmed Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
title_short Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
title_sort inhibitory effect of citrus flavonoids on the in vitro transport activity of human urate transporter 1 (urat1/slc22a12), a renal re-absorber of urate
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002704/
https://www.ncbi.nlm.nih.gov/pubmed/32047858
http://dx.doi.org/10.1038/s41538-020-0063-7
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