Cargando…

Genomic footprints of activated telomere maintenance mechanisms in cancer

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect who...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sieverling, Lina, Hong, Chen, Koser, Sandra D., Ginsbach, Philip, Kleinheinz, Kortine, Hutter, Barbara, Braun, Delia M., Cortés-Ciriano, Isidro, Xi, Ruibin, Kabbe, Rolf, Park, Peter J., Eils, Roland, Schlesner, Matthias, Brors, Benedikt, Rippe, Karsten, Jones, David T. W., Feuerbach, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002710/ https://www.ncbi.nlm.nih.gov/pubmed/32024817 http://dx.doi.org/10.1038/s41467-019-13824-9

Ejemplares similares

Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer
por: Sieverling, Lina, et al.
Publicado: (2022)

TelomereHunter – in silico estimation of telomere content and composition from cancer genomes
por: Feuerbach, Lars, et al.
Publicado: (2019)

TelNet - a database for human and yeast genes involved in telomere maintenance
por: Braun, Delia M., et al.
Publicado: (2018)

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
por: Hartlieb, Sabine A., et al.
Publicado: (2021)

Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
por: Ishaque, Naveed, et al.
Publicado: (2018)

Integrative genomic and transcriptomic analysis of leiomyosarcoma
por: Chudasama, Priya, et al.
Publicado: (2018)

Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes
por: Warnat, Patrick, et al.
Publicado: (2005)

Distributed Ledger Technology in genomics: a call for Europe
por: Thiebes, Scott, et al.
Publicado: (2019)

Bioalerts: a python library for the derivation of structural alerts from bioactivity and toxicity data sets
por: Cortes-Ciriano, Isidro
Publicado: (2016)

PML body meets telomere: The beginning of an ALTernate ending?
por: Chung, Inn, et al.
Publicado: (2012)

Formal reply to “Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX”
por: Feuerbach, Lars
Publicado: (2021)

Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance
por: Horak, Peter, et al.
Publicado: (2019)

New Insights into the Genetic Regulation of Plasmodium Falciparum Obtained by Bayesian Modeling
por: Bulashevska, Svetlana, et al.
Publicado: (2007)

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
por: Giessler, Klara M., et al.
Publicado: (2017)

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations
por: Jabs, Julia, et al.
Publicado: (2017)

KekuleScope: prediction of cancer cell line sensitivity and compound potency using convolutional neural networks trained on compound images
por: Cortés-Ciriano, Isidro, et al.
Publicado: (2019)

Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 2: a discussion of chemical and biological data
por: Bender, Andreas, et al.
Publicado: (2021)

The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
por: Haupt, Sandra, et al.
Publicado: (2022)

Hypermutation takes the driver’s seat
por: Schlesner, Matthias, et al.
Publicado: (2015)

Framework for quality assessment of whole genome cancer sequences
por: Whalley, Justin P., et al.
Publicado: (2020)

Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition
por: Deeg, Katharina I., et al.
Publicado: (2016)

Decision-Tree Based Model Analysis for Efficient Identification of Parameter Relations Leading to Different Signaling States
por: Koch, Yvonne, et al.
Publicado: (2013)

A scoping review of distributed ledger technology in genomics: thematic analysis and directions for future research
por: Beyene, Mikael, et al.
Publicado: (2022)

gtrellis: an R/Bioconductor package for making genome-level Trellis graphics
por: Gu, Zuguang, et al.
Publicado: (2016)

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes
por: Warnat, Patrick, et al.
Publicado: (2007)

A semi-supervised learning framework for quantitative structure–activity regression modelling
por: Watson, Oliver, et al.
Publicado: (2020)

QSAR-derived affinity fingerprints (part 2): modeling performance for potency prediction
por: Cortés-Ciriano, Isidro, et al.
Publicado: (2020)

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
por: Gröschel, Stefan, et al.
Publicado: (2019)

Comparison of normalization methods for Illumina BeadChip HumanHT-12 v3
por: Schmid, Ramona, et al.
Publicado: (2010)

EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations
por: Gu, Zuguang, et al.
Publicado: (2018)

Genetic and epigenetic profiling of a solitary Peutz–Jeghers colon polyp
por: Linhart, Heinz, et al.
Publicado: (2017)

Between-species differences in gene copy number are enriched among functions critical for adaptive evolution in Arabidopsis halleri
por: Suryawanshi, Vasantika, et al.
Publicado: (2016)

Role of the ESCRT Complexes in Telomere Biology
por: Dieckmann, Anna K., et al.
Publicado: (2016)

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
por: López, Cristina, et al.
Publicado: (2019)

Coverage Bias and Sensitivity of Variant Calling for Four Whole-genome Sequencing Technologies
por: Rieber, Nora, et al.
Publicado: (2013)

Experimental validation of in silico target predictions on synergistic protein targets
por: Cortes-Ciriano, Isidro, et al.
Publicado: (2013)

A decision-theoretic approach to the evaluation of machine learning algorithms in computational drug discovery
por: Watson, Oliver P, et al.
Publicado: (2019)

HostPhinder: A Phage Host Prediction Tool
por: Villarroel, Julia, et al.
Publicado: (2016)

The landscape of chromothripsis across adult cancer types
por: Voronina, Natalia, et al.
Publicado: (2020)

Proteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules
por: Paricharak, Shardul, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_77muu4ua44rp1m11va9g1arhc2