Cargando…

Divergent mutational processes distinguish hypoxic and normoxic tumours

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhandari, Vinayak, Li, Constance H., Bristow, Robert G., Boutros, Paul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002770/ https://www.ncbi.nlm.nih.gov/pubmed/32024819 http://dx.doi.org/10.1038/s41467-019-14052-x

Ejemplares similares

Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours
por: Bhandari, Vinayak, et al.
Publicado: (2022)

Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro
por: Patras, Laura, et al.
Publicado: (2020)

Supraspinal fatigue after normoxic and hypoxic exercise in humans
por: Goodall, Stuart, et al.
Publicado: (2012)

Effect of propofol and etomidate on normoxic and chronically hypoxic pulmonary artery
por: Ouédraogo, Nazinigouba, et al.
Publicado: (2006)

Fusion of Normoxic- and Hypoxic-Preconditioned Myoblasts Leads to Increased Hypertrophy
por: Pircher, Tamara, et al.
Publicado: (2022)

Differential expression of checkpoint markers in the normoxic and hypoxic microenvironment of glioblastomas
por: Petterson, Stine Asferg, et al.
Publicado: (2022)

Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro
por: Koch, S, et al.
Publicado: (2003)

Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High
por: De Smet, Stefan, et al.
Publicado: (2017)

Cardiac magnetic resonance imaging in healthy volunteers in normoxic and hypoxic exercise
por: Jaijee, Shareen, et al.
Publicado: (2016)

Scalene and sternocleidomastoid activation during normoxic and hypoxic incremental inspiratory loading
por: Basoudan, Nada, et al.
Publicado: (2020)

Glutamatergic Receptors Modulate Normoxic but Not Hypoxic Ventilation and Metabolism in Naked Mole Rats
por: Dzal, Yvonne A., et al.
Publicado: (2019)

Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions
por: Marini, Patrizia, et al.
Publicado: (2009)

Combined transcriptome and proteome analysis of yak PASMCs under hypoxic and normoxic conditions
por: Zhang, Lan, et al.
Publicado: (2022)

Quantifying the influence of mutation detection on tumour subclonal reconstruction
por: Liu, Lydia Y., et al.
Publicado: (2020)

New mechanisms of normoxic and hypoxic cGMP signalling mediated by the nitrite anion
por: Champion, Hunter
Publicado: (2013)

Effect of pre-term birth on oxidative stress responses to normoxic and hypoxic exercise
por: Martin, Agnès, et al.
Publicado: (2020)

Neuro-mechanical determinants of repeated treadmill sprints - Usefulness of an “hypoxic to normoxic recovery” approach
por: Girard, Olivier, et al.
Publicado: (2015)

Exosomes Secreted by Normoxic and Hypoxic Cardiosphere-derived Cells Have Anti-apoptotic Effect
por: Namazi, Helia, et al.
Publicado: (2018)

Different Bacterial Communities Involved in Peptide Decomposition between Normoxic and Hypoxic Coastal Waters
por: Liu, Shuting, et al.
Publicado: (2017)

T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions
por: Sener, Zeynep, et al.
Publicado: (2016)

Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study
por: Mähler, Anja, et al.
Publicado: (2018)

SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions
por: Wu, Qianqian, et al.
Publicado: (2013)

Genome-scale analyses of transcriptional start sites in Mycobacterium marinum under normoxic and hypoxic conditions
por: Huang, Shaojia, et al.
Publicado: (2021)

Time-gated Raman spectroscopy and proteomics analyses of hypoxic and normoxic renal carcinoma extracellular vesicles
por: Samoylenko, Anatoliy, et al.
Publicado: (2021)

The Effect of Hypoxic and Normoxic Culturing Conditions in Different Breast Cancer 3D Model Systems
por: Svanström, Andreas, et al.
Publicado: (2021)

The Effect of Normoxic and Hypoxic U-87 Glioblastoma Paracrine Secretion on the Modulation of Brain Endothelial Cells
por: Rado, Mariam, et al.
Publicado: (2022)

High Hemin Concentration Induces Escape from Senescence of Normoxic and Hypoxic Colon Cancer Cells
por: Borkowska, Agata, et al.
Publicado: (2022)

Regenerative potential of mesenchymal stromal cells in wound healing: unveiling the influence of normoxic and hypoxic environments
por: Mahjoor, Mohamad, et al.
Publicado: (2023)

MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions
por: Chen, Yei-Tsung, et al.
Publicado: (2015)

The Influence of High-Altitude Acclimatization on Ventilatory and Blood Oxygen Saturation Responses During Normoxic and Hypoxic Testing
por: Ušaj1, Anton, et al.
Publicado: (2016)

Acute Exhaustive Exercise under Normoxic and Normobaric Hypoxic Conditions Differentially Regulates Angiogenic Biomarkers in Humans
por: Suhr, Frank, et al.
Publicado: (2021)

Effects of Metformin on Spontaneous Ca(2+) Signals in Cultured Microglia Cells under Normoxic and Hypoxic Conditions
por: Jankeviciute, Silvija, et al.
Publicado: (2021)

Differential Effects of Normoxic versus Hypoxic Derived Breast Cancer Paracrine Factors on Brain Endothelial Cells
por: Rado, Mariam, et al.
Publicado: (2021)

Oxygen and Drug-Carrying Periodic Mesoporous Organosilicas for Enhanced Cell Viability under Normoxic and Hypoxic Conditions
por: Kumar, Ravi, et al.
Publicado: (2022)

The Paracrine Effect of Hypoxic and Normoxic Cancer Secretion on the Proliferation of Brain Endothelial Cells (bEnd.3)
por: Rado, Mariam, et al.
Publicado: (2022)

Curcumol β-cyclodextrin inclusion complex enhances radiosensitivity of esophageal cancer under hypoxic and normoxic condition
por: Su, Meng, et al.
Publicado: (2023)

Identification and characterization of differentially expressed miRNAs in HepG2 cells under normoxic and hypoxic conditions
por: Kong, Fanzhi, et al.
Publicado: (2019)

Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach
por: Ji, Zhiwei, et al.
Publicado: (2015)

GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions
por: Bustos, Viviana, et al.
Publicado: (2017)

Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions
por: Shinohara, Yuta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_739kpg3q6i1heaubdamdh3t6mc