Cargando…

Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma

Of the different types of lung cancer, lung squamous cell cancer (LUSC) has the second highest rates of morbidity and mortality, which have been increasing in recent years. Epigenetic abnormalities may serve as potential biomarkers and diagnostic and/or therapeutic targets, which may help to monitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Qingqing, Wang, Jia, Zhang, Qiujing, Wang, Fuxia, Fang, Lihua, Song, Bao, Xie, Chao, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002985/
https://www.ncbi.nlm.nih.gov/pubmed/32016477
http://dx.doi.org/10.3892/mmr.2020.10933
_version_ 1783494449337204736
author Zhu, Qingqing
Wang, Jia
Zhang, Qiujing
Wang, Fuxia
Fang, Lihua
Song, Bao
Xie, Chao
Liu, Jie
author_facet Zhu, Qingqing
Wang, Jia
Zhang, Qiujing
Wang, Fuxia
Fang, Lihua
Song, Bao
Xie, Chao
Liu, Jie
author_sort Zhu, Qingqing
collection PubMed
description Of the different types of lung cancer, lung squamous cell cancer (LUSC) has the second highest rates of morbidity and mortality, which have been increasing in recent years. Epigenetic abnormalities may serve as potential biomarkers and diagnostic and/or therapeutic targets, which may help to monitor and improve the prognosis of patients with cancer. In the present study, data were obtained from The Cancer Genome Atlas database and survival and joint survival analyses were conducted using the R MethylMix package. Peptidase, mitochondrial processing a subunit pseudogene 1 (PMPCAP1), sosondowah ankyrin repeat domain family member C (SOWAHC) and zinc finger protein (ZNF) 454 were identified as independent prognosis-related hub methylation-driven genes (MDGs). Of these three genes, PMPCAP1 and SOWAHC, characterized by hypomethylation and high expression levels, were associated with poor prognosis in patients with LUSC, whilst ZNF454 was associated with an improved prognosis. In addition, pathway enrichment analysis suggested that PMPCAP1, SOWAHC and ZNF454 were primarily involved in gene expression or transcription pathways. Furthermore, 5, 1 and 10 key methylation sites of PMPCAP1, SOWAHC and ZNF454, respectively, were confirmed to be significantly relevant to gene expression, establishing a basis for further investigation into the mechanisms and more precise targets of these 3 genes. In conclusion, the MDGs PMPCAP1, SOWAHC and ZNF454 may be potential prognostic biomarkers of LUSC for guiding diagnosis and therapy options, as well as providing a theoretical basis for further investigation.
format Online
Article
Text
id pubmed-7002985
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-70029852020-02-12 Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma Zhu, Qingqing Wang, Jia Zhang, Qiujing Wang, Fuxia Fang, Lihua Song, Bao Xie, Chao Liu, Jie Mol Med Rep Articles Of the different types of lung cancer, lung squamous cell cancer (LUSC) has the second highest rates of morbidity and mortality, which have been increasing in recent years. Epigenetic abnormalities may serve as potential biomarkers and diagnostic and/or therapeutic targets, which may help to monitor and improve the prognosis of patients with cancer. In the present study, data were obtained from The Cancer Genome Atlas database and survival and joint survival analyses were conducted using the R MethylMix package. Peptidase, mitochondrial processing a subunit pseudogene 1 (PMPCAP1), sosondowah ankyrin repeat domain family member C (SOWAHC) and zinc finger protein (ZNF) 454 were identified as independent prognosis-related hub methylation-driven genes (MDGs). Of these three genes, PMPCAP1 and SOWAHC, characterized by hypomethylation and high expression levels, were associated with poor prognosis in patients with LUSC, whilst ZNF454 was associated with an improved prognosis. In addition, pathway enrichment analysis suggested that PMPCAP1, SOWAHC and ZNF454 were primarily involved in gene expression or transcription pathways. Furthermore, 5, 1 and 10 key methylation sites of PMPCAP1, SOWAHC and ZNF454, respectively, were confirmed to be significantly relevant to gene expression, establishing a basis for further investigation into the mechanisms and more precise targets of these 3 genes. In conclusion, the MDGs PMPCAP1, SOWAHC and ZNF454 may be potential prognostic biomarkers of LUSC for guiding diagnosis and therapy options, as well as providing a theoretical basis for further investigation. D.A. Spandidos 2020-03 2020-01-13 /pmc/articles/PMC7002985/ /pubmed/32016477 http://dx.doi.org/10.3892/mmr.2020.10933 Text en Copyright: © Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhu, Qingqing
Wang, Jia
Zhang, Qiujing
Wang, Fuxia
Fang, Lihua
Song, Bao
Xie, Chao
Liu, Jie
Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma
title Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma
title_full Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma
title_fullStr Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma
title_full_unstemmed Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma
title_short Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma
title_sort methylation-driven genes pmpcap1, sowahc and znf454 as potential prognostic biomarkers in lung squamous cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002985/
https://www.ncbi.nlm.nih.gov/pubmed/32016477
http://dx.doi.org/10.3892/mmr.2020.10933
work_keys_str_mv AT zhuqingqing methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT wangjia methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT zhangqiujing methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT wangfuxia methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT fanglihua methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT songbao methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT xiechao methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma
AT liujie methylationdrivengenespmpcap1sowahcandznf454aspotentialprognosticbiomarkersinlungsquamouscellcarcinoma