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Roles of inflammation factors in melanogenesis

The occurrence of hyperpigmentation or hypopigmentation after inflammation is a common condition in dermatology and cosmetology. Since the exact mechanism of its occurrence is not yet known, prevention and treatment are troublesome. Previous studies have confirmed that α-melanocyte-stimulating hormo...

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Autores principales: Fu, Chuhan, Chen, Jing, Lu, Jianyun, Yi, Lu, Tong, Xiaoliang, Kang, Liyang, Pei, Shiyao, Ouyang, Yujie, Jiang, Ling, Ding, Yufang, Zhao, Xiaojiao, Li, Si, Yang, Yan, Huang, Jinhua, Zeng, Qinghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002987/
https://www.ncbi.nlm.nih.gov/pubmed/32016458
http://dx.doi.org/10.3892/mmr.2020.10950
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author Fu, Chuhan
Chen, Jing
Lu, Jianyun
Yi, Lu
Tong, Xiaoliang
Kang, Liyang
Pei, Shiyao
Ouyang, Yujie
Jiang, Ling
Ding, Yufang
Zhao, Xiaojiao
Li, Si
Yang, Yan
Huang, Jinhua
Zeng, Qinghai
author_facet Fu, Chuhan
Chen, Jing
Lu, Jianyun
Yi, Lu
Tong, Xiaoliang
Kang, Liyang
Pei, Shiyao
Ouyang, Yujie
Jiang, Ling
Ding, Yufang
Zhao, Xiaojiao
Li, Si
Yang, Yan
Huang, Jinhua
Zeng, Qinghai
author_sort Fu, Chuhan
collection PubMed
description The occurrence of hyperpigmentation or hypopigmentation after inflammation is a common condition in dermatology and cosmetology. Since the exact mechanism of its occurrence is not yet known, prevention and treatment are troublesome. Previous studies have confirmed that α-melanocyte-stimulating hormone, stem cell factor and other factors can promote melanogenesis-related gene expression through the activation of signaling pathways. Recent studies have revealed that a variety of inflammatory mediators can also participate in the regulation of melanogenesis in melanocytes. In this review, we summarized that interleukin-18, interleukin-33, granulocyte-macrophage colony stimulating factor, interferon-γ, prostaglandin E2 have the effect of promoting melanogenesis, while interleukin-1, interleukin-4, interleukin-6, interleukin-17 and tumor necrosis factor can inhibit melanogenesis. Further studies have found that these inflammatory factors may activate or inhibit melanogenesis-related signaling pathways (such as protein kinase A and mitogen activated protein kinase) by binding to corresponding receptors, thereby promoting or inhibiting the expression of melanogenesis-related genes and regulating skin pigmentation processes. This suggests that the development of drugs or treatment methods from the perspective of regulating inflammation can provide new ideas and new targets for the treatment of pigmented dermatosis. This review outlines the current understanding of the inflammation factors' roles in melanogenesis.
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spelling pubmed-70029872020-02-12 Roles of inflammation factors in melanogenesis Fu, Chuhan Chen, Jing Lu, Jianyun Yi, Lu Tong, Xiaoliang Kang, Liyang Pei, Shiyao Ouyang, Yujie Jiang, Ling Ding, Yufang Zhao, Xiaojiao Li, Si Yang, Yan Huang, Jinhua Zeng, Qinghai Mol Med Rep Review The occurrence of hyperpigmentation or hypopigmentation after inflammation is a common condition in dermatology and cosmetology. Since the exact mechanism of its occurrence is not yet known, prevention and treatment are troublesome. Previous studies have confirmed that α-melanocyte-stimulating hormone, stem cell factor and other factors can promote melanogenesis-related gene expression through the activation of signaling pathways. Recent studies have revealed that a variety of inflammatory mediators can also participate in the regulation of melanogenesis in melanocytes. In this review, we summarized that interleukin-18, interleukin-33, granulocyte-macrophage colony stimulating factor, interferon-γ, prostaglandin E2 have the effect of promoting melanogenesis, while interleukin-1, interleukin-4, interleukin-6, interleukin-17 and tumor necrosis factor can inhibit melanogenesis. Further studies have found that these inflammatory factors may activate or inhibit melanogenesis-related signaling pathways (such as protein kinase A and mitogen activated protein kinase) by binding to corresponding receptors, thereby promoting or inhibiting the expression of melanogenesis-related genes and regulating skin pigmentation processes. This suggests that the development of drugs or treatment methods from the perspective of regulating inflammation can provide new ideas and new targets for the treatment of pigmented dermatosis. This review outlines the current understanding of the inflammation factors' roles in melanogenesis. D.A. Spandidos 2020-03 2020-01-17 /pmc/articles/PMC7002987/ /pubmed/32016458 http://dx.doi.org/10.3892/mmr.2020.10950 Text en Copyright: © Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Fu, Chuhan
Chen, Jing
Lu, Jianyun
Yi, Lu
Tong, Xiaoliang
Kang, Liyang
Pei, Shiyao
Ouyang, Yujie
Jiang, Ling
Ding, Yufang
Zhao, Xiaojiao
Li, Si
Yang, Yan
Huang, Jinhua
Zeng, Qinghai
Roles of inflammation factors in melanogenesis
title Roles of inflammation factors in melanogenesis
title_full Roles of inflammation factors in melanogenesis
title_fullStr Roles of inflammation factors in melanogenesis
title_full_unstemmed Roles of inflammation factors in melanogenesis
title_short Roles of inflammation factors in melanogenesis
title_sort roles of inflammation factors in melanogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002987/
https://www.ncbi.nlm.nih.gov/pubmed/32016458
http://dx.doi.org/10.3892/mmr.2020.10950
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