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Acquired Hemophilia A with Gastrointestinal Bleeding

Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory–Weiss syndrome, and malignancy. On the contrary, acquired hemophilia A is a very rare hemorrhagic disease, which usually manifests with musculocutaneous bleeding, caused by autoan...

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Detalles Bibliográficos
Autores principales: Park, Narae, Jang, Jin Seok, Cha, Jae Hwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Gastrointestinal Endoscopy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003004/
https://www.ncbi.nlm.nih.gov/pubmed/31280527
http://dx.doi.org/10.5946/ce.2019.036
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author Park, Narae
Jang, Jin Seok
Cha, Jae Hwang
author_facet Park, Narae
Jang, Jin Seok
Cha, Jae Hwang
author_sort Park, Narae
collection PubMed
description Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory–Weiss syndrome, and malignancy. On the contrary, acquired hemophilia A is a very rare hemorrhagic disease, which usually manifests with musculocutaneous bleeding, caused by autoantibodies against coagulation factor VIII. A 78-year-old man presented to the Emergency Department with melena. Dieulafoy’s lesions were observed on, and endoscopic cauterization was performed. However, the patient complained of back pain and symptoms indicative of upper gastrointestinal bleeding. Abdominopelvic computed tomography was performed, and hematoma in the psoas muscle was detected. Antibodies against coagulation factor VIII were confirmed with a blood test, and the diagnosis of acquired hemophilia A was made. Here, we report a case of acquired hemophilia A presenting with upper gastrointestinal bleeding symptoms and present a brief review of literature.
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spelling pubmed-70030042020-02-12 Acquired Hemophilia A with Gastrointestinal Bleeding Park, Narae Jang, Jin Seok Cha, Jae Hwang Clin Endosc Case Report Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory–Weiss syndrome, and malignancy. On the contrary, acquired hemophilia A is a very rare hemorrhagic disease, which usually manifests with musculocutaneous bleeding, caused by autoantibodies against coagulation factor VIII. A 78-year-old man presented to the Emergency Department with melena. Dieulafoy’s lesions were observed on, and endoscopic cauterization was performed. However, the patient complained of back pain and symptoms indicative of upper gastrointestinal bleeding. Abdominopelvic computed tomography was performed, and hematoma in the psoas muscle was detected. Antibodies against coagulation factor VIII were confirmed with a blood test, and the diagnosis of acquired hemophilia A was made. Here, we report a case of acquired hemophilia A presenting with upper gastrointestinal bleeding symptoms and present a brief review of literature. Korean Society of Gastrointestinal Endoscopy 2020-01 2019-07-08 /pmc/articles/PMC7003004/ /pubmed/31280527 http://dx.doi.org/10.5946/ce.2019.036 Text en Copyright © 2020 Korean Society of Gastrointestinal Endoscopy This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Park, Narae
Jang, Jin Seok
Cha, Jae Hwang
Acquired Hemophilia A with Gastrointestinal Bleeding
title Acquired Hemophilia A with Gastrointestinal Bleeding
title_full Acquired Hemophilia A with Gastrointestinal Bleeding
title_fullStr Acquired Hemophilia A with Gastrointestinal Bleeding
title_full_unstemmed Acquired Hemophilia A with Gastrointestinal Bleeding
title_short Acquired Hemophilia A with Gastrointestinal Bleeding
title_sort acquired hemophilia a with gastrointestinal bleeding
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003004/
https://www.ncbi.nlm.nih.gov/pubmed/31280527
http://dx.doi.org/10.5946/ce.2019.036
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