Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitr...

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Detalles Bibliográficos
Autores principales: Falcone, Marco, Tiseo, Giusy, Antonelli, Alberto, Giordano, Cesira, Di Pilato, Vincenzo, Bertolucci, Pietro, Parisio, Eva Maria, Leonildi, Alessandro, Aiezza, Noemi, Baccani, Ilaria, Tagliaferri, Enrico, Righi, Lorenzo, Forni, Silvia, Sani, Spartaco, Mechi, Maria Teresa, Pieralli, Filippo, Barnini, Simona, Rossolini, Gian Maria, Menichetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003035/
https://www.ncbi.nlm.nih.gov/pubmed/32042848
http://dx.doi.org/10.1093/ofid/ofaa011
Descripción
Sumario:Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

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