Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitr...

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Autores principales: Falcone, Marco, Tiseo, Giusy, Antonelli, Alberto, Giordano, Cesira, Di Pilato, Vincenzo, Bertolucci, Pietro, Parisio, Eva Maria, Leonildi, Alessandro, Aiezza, Noemi, Baccani, Ilaria, Tagliaferri, Enrico, Righi, Lorenzo, Forni, Silvia, Sani, Spartaco, Mechi, Maria Teresa, Pieralli, Filippo, Barnini, Simona, Rossolini, Gian Maria, Menichetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003035/
https://www.ncbi.nlm.nih.gov/pubmed/32042848
http://dx.doi.org/10.1093/ofid/ofaa011
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author Falcone, Marco
Tiseo, Giusy
Antonelli, Alberto
Giordano, Cesira
Di Pilato, Vincenzo
Bertolucci, Pietro
Parisio, Eva Maria
Leonildi, Alessandro
Aiezza, Noemi
Baccani, Ilaria
Tagliaferri, Enrico
Righi, Lorenzo
Forni, Silvia
Sani, Spartaco
Mechi, Maria Teresa
Pieralli, Filippo
Barnini, Simona
Rossolini, Gian Maria
Menichetti, Francesco
author_facet Falcone, Marco
Tiseo, Giusy
Antonelli, Alberto
Giordano, Cesira
Di Pilato, Vincenzo
Bertolucci, Pietro
Parisio, Eva Maria
Leonildi, Alessandro
Aiezza, Noemi
Baccani, Ilaria
Tagliaferri, Enrico
Righi, Lorenzo
Forni, Silvia
Sani, Spartaco
Mechi, Maria Teresa
Pieralli, Filippo
Barnini, Simona
Rossolini, Gian Maria
Menichetti, Francesco
author_sort Falcone, Marco
collection PubMed
description Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.
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spelling pubmed-70030352020-02-10 Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak Falcone, Marco Tiseo, Giusy Antonelli, Alberto Giordano, Cesira Di Pilato, Vincenzo Bertolucci, Pietro Parisio, Eva Maria Leonildi, Alessandro Aiezza, Noemi Baccani, Ilaria Tagliaferri, Enrico Righi, Lorenzo Forni, Silvia Sani, Spartaco Mechi, Maria Teresa Pieralli, Filippo Barnini, Simona Rossolini, Gian Maria Menichetti, Francesco Open Forum Infect Dis Brief Report Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option. Oxford University Press 2020-01-21 /pmc/articles/PMC7003035/ /pubmed/32042848 http://dx.doi.org/10.1093/ofid/ofaa011 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Falcone, Marco
Tiseo, Giusy
Antonelli, Alberto
Giordano, Cesira
Di Pilato, Vincenzo
Bertolucci, Pietro
Parisio, Eva Maria
Leonildi, Alessandro
Aiezza, Noemi
Baccani, Ilaria
Tagliaferri, Enrico
Righi, Lorenzo
Forni, Silvia
Sani, Spartaco
Mechi, Maria Teresa
Pieralli, Filippo
Barnini, Simona
Rossolini, Gian Maria
Menichetti, Francesco
Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
title Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
title_full Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
title_fullStr Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
title_full_unstemmed Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
title_short Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
title_sort clinical features and outcomes of bloodstream infections caused by new delhi metallo-β-lactamase–producing enterobacterales during a regional outbreak
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003035/
https://www.ncbi.nlm.nih.gov/pubmed/32042848
http://dx.doi.org/10.1093/ofid/ofaa011
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