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Dexmedetomidine alleviates cisplatin-induced acute kidney injury by attenuating endoplasmic reticulum stress-induced apoptosis via the α(2)AR/PI3K/AKT pathway

Cisplatin (CP) is an effective antineoplastic agent; however, CP-induced acute kidney injury (AKI) seriously affects the prognosis of patients with cancer. Endoplasmic reticulum (ER) stress (ERS)-induced apoptosis serves a pivotal role in the pathogenesis of CP-induced AKI. Dexmedetomidine (Dex), a...

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Detalles Bibliográficos
Autores principales:	Chai, Yejing, Zhu, Kangsheng, Li, Chao, Wang, Xiaofan, Shen, Junmei, Yong, Fangfang, Jia, Huiqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003053/ https://www.ncbi.nlm.nih.gov/pubmed/32016445 http://dx.doi.org/10.3892/mmr.2020.10962

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