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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses. Apparently, the level of self-reactivity of mature T cells must be tightly balanced. Our mathematical model and experimental...

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Detalles Bibliográficos
Autores principales:	Horkova, Veronika, Drobek, Ales, Mueller, Daniel, Gubser, Celine, Niederlova, Veronika, Wyss, Lena, King, Carolyn G., Zehn, Dietmar, Stepanek, Ondrej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003063/ https://www.ncbi.nlm.nih.gov/pubmed/32023465 http://dx.doi.org/10.1016/j.celrep.2020.01.008

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