Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Mechanistic or mammalian target of rapamycin complex 1 (mTORC1) is an important regulator of effector functions, proliferation, and cellular metabolism in macrophages. The biochemical processes that are controlled by mTORC1 are still being defined. Here, we demonstrate that integrative multiomics in...

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Detalles Bibliográficos
Autores principales: Wilson, Jayne Louise, Nägele, Thomas, Linke, Monika, Demel, Florian, Fritsch, Stephanie D., Mayr, Hannah Katharina, Cai, Zhengnan, Katholnig, Karl, Sun, Xiaoliang, Fragner, Lena, Miller, Anne, Haschemi, Arvand, Popa, Alexandra, Bergthaler, Andreas, Hengstschläger, Markus, Weichhart, Thomas, Weckwerth, Wolfram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003064/
https://www.ncbi.nlm.nih.gov/pubmed/32023468
http://dx.doi.org/10.1016/j.celrep.2020.01.011

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