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Effect of Stellaria media Tea on Lipid Profile in Rats
BACKGROUND: In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media)...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003252/ https://www.ncbi.nlm.nih.gov/pubmed/32047525 http://dx.doi.org/10.1155/2020/5109328 |
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author | Demján, Virág Kiss, Tivadar Siska, Andrea Szabó, Márton Richárd Sárközy, Márta Földesi, Imre Csupor, Dezső Csont, Tamás |
author_facet | Demján, Virág Kiss, Tivadar Siska, Andrea Szabó, Márton Richárd Sárközy, Márta Földesi, Imre Csupor, Dezső Csont, Tamás |
author_sort | Demján, Virág |
collection | PubMed |
description | BACKGROUND: In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of RESULTS: Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of CONCLUSION: Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia. |
format | Online Article Text |
id | pubmed-7003252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70032522020-02-11 Effect of Stellaria media Tea on Lipid Profile in Rats Demján, Virág Kiss, Tivadar Siska, Andrea Szabó, Márton Richárd Sárközy, Márta Földesi, Imre Csupor, Dezső Csont, Tamás Evid Based Complement Alternat Med Research Article BACKGROUND: In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of RESULTS: Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of CONCLUSION: Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia. Hindawi 2020-01-24 /pmc/articles/PMC7003252/ /pubmed/32047525 http://dx.doi.org/10.1155/2020/5109328 Text en Copyright © 2020 Virág Demján et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Demján, Virág Kiss, Tivadar Siska, Andrea Szabó, Márton Richárd Sárközy, Márta Földesi, Imre Csupor, Dezső Csont, Tamás Effect of Stellaria media Tea on Lipid Profile in Rats |
title | Effect of Stellaria media Tea on Lipid Profile in Rats |
title_full | Effect of Stellaria media Tea on Lipid Profile in Rats |
title_fullStr | Effect of Stellaria media Tea on Lipid Profile in Rats |
title_full_unstemmed | Effect of Stellaria media Tea on Lipid Profile in Rats |
title_short | Effect of Stellaria media Tea on Lipid Profile in Rats |
title_sort | effect of stellaria media tea on lipid profile in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003252/ https://www.ncbi.nlm.nih.gov/pubmed/32047525 http://dx.doi.org/10.1155/2020/5109328 |
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