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Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE)
PURPOSE: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) cohort was established in Italy in 2016 to evaluate the overall efficacy and tolerability of dolutegravir (DTG)-based antiretroviral (ARV) regimens in clinical practice. PARTICIPANTS: The...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003384/ https://www.ncbi.nlm.nih.gov/pubmed/31796476 http://dx.doi.org/10.1136/bmjopen-2019-029960 |
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author | Ciccullo, Arturo Baldin, Gianmaria Capetti, Amedeo Borghi, Vanni Sterrantino, Gaetana Latini, Alessandra Madeddu, Giordano Celani, Luigi Vignale, Francesca Rossetti, Barbara Dusina, Alex Cossu, Maria Vittoria Restelli, Sibilla Gennari, William Lagi, Filippo Giacomelli, Andrea Colafigli, Manuela Brescini, Lucia Borghetti, Alberto Mussini, Cristina Rusconi, Stefano Di Giambenedetto, Simona |
author_facet | Ciccullo, Arturo Baldin, Gianmaria Capetti, Amedeo Borghi, Vanni Sterrantino, Gaetana Latini, Alessandra Madeddu, Giordano Celani, Luigi Vignale, Francesca Rossetti, Barbara Dusina, Alex Cossu, Maria Vittoria Restelli, Sibilla Gennari, William Lagi, Filippo Giacomelli, Andrea Colafigli, Manuela Brescini, Lucia Borghetti, Alberto Mussini, Cristina Rusconi, Stefano Di Giambenedetto, Simona |
author_sort | Ciccullo, Arturo |
collection | PubMed |
description | PURPOSE: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) cohort was established in Italy in 2016 to evaluate the overall efficacy and tolerability of dolutegravir (DTG)-based antiretroviral (ARV) regimens in clinical practice. PARTICIPANTS: The ODOACRE cohort enrols all adult HIV-1-infected patients, both treatment-naïve and treatment-experienced, starting a DTG-based ARV regimen, in 11 clinical centres in Italy from 2014. FINDINGS TO DATE: In recent years, various works by the ODOACRE cohort have been produced, demonstrating the high efficacy and tolerability of DTG-based ARV regimens in clinical practice, both in ART-naïve (in the setting of acute HIV-1 infection and late presenters patient) and experienced patients. We confirmed the virological efficacy of DTG-based regimens and we evaluated predictors of virological failure. We investigated cause of discontinuation and evaluated tolerability and metabolic profile of the regimens. Within these investigations, we explored particularly the use of DTG in simplification in two-drug regimen with either rilpivirine or lamivudine. We also compared DTG-based regimens with other integrase inhibitors in clinical practice. FUTURE PLANS: To continue to study long-term efficacy and tolerability of DTG-based regimens is the purpose of the ODOACRE cohort. |
format | Online Article Text |
id | pubmed-7003384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-70033842020-02-25 Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) Ciccullo, Arturo Baldin, Gianmaria Capetti, Amedeo Borghi, Vanni Sterrantino, Gaetana Latini, Alessandra Madeddu, Giordano Celani, Luigi Vignale, Francesca Rossetti, Barbara Dusina, Alex Cossu, Maria Vittoria Restelli, Sibilla Gennari, William Lagi, Filippo Giacomelli, Andrea Colafigli, Manuela Brescini, Lucia Borghetti, Alberto Mussini, Cristina Rusconi, Stefano Di Giambenedetto, Simona BMJ Open HIV/AIDS PURPOSE: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) cohort was established in Italy in 2016 to evaluate the overall efficacy and tolerability of dolutegravir (DTG)-based antiretroviral (ARV) regimens in clinical practice. PARTICIPANTS: The ODOACRE cohort enrols all adult HIV-1-infected patients, both treatment-naïve and treatment-experienced, starting a DTG-based ARV regimen, in 11 clinical centres in Italy from 2014. FINDINGS TO DATE: In recent years, various works by the ODOACRE cohort have been produced, demonstrating the high efficacy and tolerability of DTG-based ARV regimens in clinical practice, both in ART-naïve (in the setting of acute HIV-1 infection and late presenters patient) and experienced patients. We confirmed the virological efficacy of DTG-based regimens and we evaluated predictors of virological failure. We investigated cause of discontinuation and evaluated tolerability and metabolic profile of the regimens. Within these investigations, we explored particularly the use of DTG in simplification in two-drug regimen with either rilpivirine or lamivudine. We also compared DTG-based regimens with other integrase inhibitors in clinical practice. FUTURE PLANS: To continue to study long-term efficacy and tolerability of DTG-based regimens is the purpose of the ODOACRE cohort. BMJ Publishing Group 2019-12-02 /pmc/articles/PMC7003384/ /pubmed/31796476 http://dx.doi.org/10.1136/bmjopen-2019-029960 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | HIV/AIDS Ciccullo, Arturo Baldin, Gianmaria Capetti, Amedeo Borghi, Vanni Sterrantino, Gaetana Latini, Alessandra Madeddu, Giordano Celani, Luigi Vignale, Francesca Rossetti, Barbara Dusina, Alex Cossu, Maria Vittoria Restelli, Sibilla Gennari, William Lagi, Filippo Giacomelli, Andrea Colafigli, Manuela Brescini, Lucia Borghetti, Alberto Mussini, Cristina Rusconi, Stefano Di Giambenedetto, Simona Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) |
title | Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) |
title_full | Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) |
title_fullStr | Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) |
title_full_unstemmed | Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) |
title_short | Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) |
title_sort | cohort profile: the observational cohort for the study of dolutegravir in antiretroviral combination regimens (odoacre) |
topic | HIV/AIDS |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003384/ https://www.ncbi.nlm.nih.gov/pubmed/31796476 http://dx.doi.org/10.1136/bmjopen-2019-029960 |
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