Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

BACKGROUND: Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle. However, it remains unclear whether and how inhibition of PAI-1 suppresses bladder tumorigenesis. METHODS: To elucidate the therapeutic...

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Detalles Bibliográficos
Autores principales: Furuya, Hideki, Hayashi, Kazukuni, Shimizu, Yoshiko, Kim, Nari, Tsukikawa, Yutaro, Chen, Runpu, Sun, Yijun, Chan, Owen T. M., Pagano, Ian, Peres, Rafael, Hokutan, Kanani, Igari, Fumie, Chan, Keith S., Rosser, Charles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003426/
https://www.ncbi.nlm.nih.gov/pubmed/32024545
http://dx.doi.org/10.1186/s12967-020-02239-6

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