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Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication

Individuals with chronic atrophic gastritis who are negative for active H. pylori infection with no history of eradication therapy have been identified in clinical practice. By excluding false‐negative and autoimmune gastritis cases, it can be surmised that most of these patients have experienced un...

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Autores principales: Kishikawa, Hiroshi, Ojiro, Keisuke, Nakamura, Kenji, Katayama, Tadashi, Arahata, Kyoko, Takarabe, Sakiko, Miura, Soichiro, Kanai, Takanori, Nishida, Jiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003427/
https://www.ncbi.nlm.nih.gov/pubmed/31680399
http://dx.doi.org/10.1111/hel.12669
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author Kishikawa, Hiroshi
Ojiro, Keisuke
Nakamura, Kenji
Katayama, Tadashi
Arahata, Kyoko
Takarabe, Sakiko
Miura, Soichiro
Kanai, Takanori
Nishida, Jiro
author_facet Kishikawa, Hiroshi
Ojiro, Keisuke
Nakamura, Kenji
Katayama, Tadashi
Arahata, Kyoko
Takarabe, Sakiko
Miura, Soichiro
Kanai, Takanori
Nishida, Jiro
author_sort Kishikawa, Hiroshi
collection PubMed
description Individuals with chronic atrophic gastritis who are negative for active H. pylori infection with no history of eradication therapy have been identified in clinical practice. By excluding false‐negative and autoimmune gastritis cases, it can be surmised that most of these patients have experienced unintentional eradication of H. pylori after antibiotic treatment for other infectious disease, unreported successful eradication, or H. pylori that spontaneously disappeared. These patients are considered to have previous H. pylori infection–induced atrophic gastritis. In this work, we define these cases based on the following criteria: absence of previous H. pylori eradication; atrophic changes on endoscopy or histologic confirmation of glandular atrophy; negative for a current H. pylori infection diagnosed in the absence of proton‐pump inhibitors or antibiotics; and absence of localized corpus atrophy, positivity for autoantibodies, or characteristic histologic findings suggestive of autoimmune gastritis. The risk of developing gastric cancer depends on the atrophic grade. The reported rate of developing gastric cancer is 0.31%‐0.62% per year for successfully eradicated severely atrophic cases (pathophysiologically equal to unintentionally eradicated cases and unreported eradicated cases), and 0.53%‐0.87% per year for spontaneously resolved cases due to severe atrophy. Therefore, for previous H. pylori infection–induced atrophic gastritis cases, we recommend endoscopic surveillance every 3 years for high‐risk patients, including those with endoscopically severe atrophy or intestinal metaplasia. Because of the difficulty involved in the endoscopic diagnosis of gastric cancer in cases of previous infection, appropriate monitoring of the high‐risk subgroup of this understudied population is especially important.
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spelling pubmed-70034272020-02-10 Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication Kishikawa, Hiroshi Ojiro, Keisuke Nakamura, Kenji Katayama, Tadashi Arahata, Kyoko Takarabe, Sakiko Miura, Soichiro Kanai, Takanori Nishida, Jiro Helicobacter Review Individuals with chronic atrophic gastritis who are negative for active H. pylori infection with no history of eradication therapy have been identified in clinical practice. By excluding false‐negative and autoimmune gastritis cases, it can be surmised that most of these patients have experienced unintentional eradication of H. pylori after antibiotic treatment for other infectious disease, unreported successful eradication, or H. pylori that spontaneously disappeared. These patients are considered to have previous H. pylori infection–induced atrophic gastritis. In this work, we define these cases based on the following criteria: absence of previous H. pylori eradication; atrophic changes on endoscopy or histologic confirmation of glandular atrophy; negative for a current H. pylori infection diagnosed in the absence of proton‐pump inhibitors or antibiotics; and absence of localized corpus atrophy, positivity for autoantibodies, or characteristic histologic findings suggestive of autoimmune gastritis. The risk of developing gastric cancer depends on the atrophic grade. The reported rate of developing gastric cancer is 0.31%‐0.62% per year for successfully eradicated severely atrophic cases (pathophysiologically equal to unintentionally eradicated cases and unreported eradicated cases), and 0.53%‐0.87% per year for spontaneously resolved cases due to severe atrophy. Therefore, for previous H. pylori infection–induced atrophic gastritis cases, we recommend endoscopic surveillance every 3 years for high‐risk patients, including those with endoscopically severe atrophy or intestinal metaplasia. Because of the difficulty involved in the endoscopic diagnosis of gastric cancer in cases of previous infection, appropriate monitoring of the high‐risk subgroup of this understudied population is especially important. John Wiley and Sons Inc. 2019-11-03 2020-02 /pmc/articles/PMC7003427/ /pubmed/31680399 http://dx.doi.org/10.1111/hel.12669 Text en © 2019 The Authors. Helicobacter published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kishikawa, Hiroshi
Ojiro, Keisuke
Nakamura, Kenji
Katayama, Tadashi
Arahata, Kyoko
Takarabe, Sakiko
Miura, Soichiro
Kanai, Takanori
Nishida, Jiro
Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
title Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
title_full Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
title_fullStr Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
title_full_unstemmed Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
title_short Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
title_sort previous helicobacter pylori infection–induced atrophic gastritis: a distinct disease entity in an understudied population without a history of eradication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003427/
https://www.ncbi.nlm.nih.gov/pubmed/31680399
http://dx.doi.org/10.1111/hel.12669
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