Enhancing Protein A performance in mAb processing: A method to reduce and rapidly evaluate host cell DNA levels during primary clarification

The use and impact of 3M™ Emphaze™ AEX Hybrid Purifier, a single‐use, fully synthetic chromatographic product, was explored to reduce host cell DNA (HC‐DNA) concentration during the primary clarification of a monoclonal antibody (mAb). An approximately 5‐log reduction in HC‐DNA was achieved at an Em...

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Detalles Bibliográficos
Autores principales: Koehler, Kenneth C., Jokondo, Zona, Narayan, Janani, Voloshin, Alexei M., Castro‐Forero, Angelines A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003430/
https://www.ncbi.nlm.nih.gov/pubmed/31276322
http://dx.doi.org/10.1002/btpr.2882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003430/
https://www.ncbi.nlm.nih.gov/pubmed/31276322
http://dx.doi.org/10.1002/btpr.2882

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