Combined Enzyme- and Transition Metal-Catalyzed Strategy for the Enantioselective Syntheses of Nitrogen Heterocycles: (−)-Coniine, DAB-1, and Nectrisine

[Image: see text] The enantioselective syntheses of (−)-coniine, DAB-1, and nectrisine have been developed, utilizing a complementary strategy of enzyme- and transition metal-catalyzed reactions. The initial stereocenter was set with >99% enantioselectivity via an enzyme-catalyzed hydrocyanation...

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Detalles Bibliográficos
Autores principales: Deardorff, Donald R., Niman, Scott W., Paulsen, Mark I., Sookezian, Anasheh, Whalen, Meghan E., Finlayson, Christopher J., Frivold, Collrane, Brown, Hilary C., Cannon, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003507/
https://www.ncbi.nlm.nih.gov/pubmed/32039338
http://dx.doi.org/10.1021/acsomega.9b03990

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