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The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study

BACKGROUND: Pathogenesis of cardiovascular diseases (CVDs) may be indicated by lipoprotein-associated phospholipase A2 (Lp-PLA2), serving as an inflammatory biomarker. However, the general dietary predictors of Lp-PLA2 have not been investigated so far. The aim of the present study is to investigate...

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Autores principales: Seyedi, Seyed Hashem Sezavar, Mottaghi, Azadeh, Mirmiran, Parvin, Hedayati, Mehdi, Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003539/
https://www.ncbi.nlm.nih.gov/pubmed/32055243
http://dx.doi.org/10.4103/jrms.JRMS_256_19
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author Seyedi, Seyed Hashem Sezavar
Mottaghi, Azadeh
Mirmiran, Parvin
Hedayati, Mehdi
Azizi, Fereidoun
author_facet Seyedi, Seyed Hashem Sezavar
Mottaghi, Azadeh
Mirmiran, Parvin
Hedayati, Mehdi
Azizi, Fereidoun
author_sort Seyedi, Seyed Hashem Sezavar
collection PubMed
description BACKGROUND: Pathogenesis of cardiovascular diseases (CVDs) may be indicated by lipoprotein-associated phospholipase A2 (Lp-PLA2), serving as an inflammatory biomarker. However, the general dietary predictors of Lp-PLA2 have not been investigated so far. The aim of the present study is to investigate the relationship between the serum levels of Lp-PLA2 and dietary patterns in adults with cardiovascular risk factors. MATERIALS AND METHODS: Dietary patterns extracted using factor analysis and serum levels of Lp-PAL2 in 470 adults aged 40–70 years who participated in the 5(th) phase of the Tehran Lipid and Glucose Study (2011–2014) were determined. Associations between the dietary patterns and serum levels of Lp-PAL2 considering some confounder factors were evaluated. RESULTS: The results showed that Western and semi-Mediterranean dietary patterns had significant effects on changes in Lp-PLA2 levels in univariate analyses. In multivariate analyses, after adjusting for age, sex, total cholesterol, low-density lipoprotein cholesterol, body mass index and physical activity, energy intake, hormone therapy for women, and taking blood lipid-lowering drugs as potential confounders, the Western dietary pattern remained a significant factor influencing the Lp-PLA2 level (β value: 1.65, 95% confidence interval: 1.12, 1.89; P < 0.05). Moreover, after adjustment for the mentioned confounder factors, the effect of the semi-Mediterranean dietary pattern on Lp-PLA2 disappeared. CONCLUSION: It can be concluded that the Western dietary pattern is associated with higher Lp-PLA2 levels. We recommend that adults eat less carbonated drinks, fast foods, salty snacks, mayonnaise, and organ meat to counteract increased serum Lp-PLA2 levels, which are directly associated with vascular inflammation and CVDs.
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spelling pubmed-70035392020-02-13 The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study Seyedi, Seyed Hashem Sezavar Mottaghi, Azadeh Mirmiran, Parvin Hedayati, Mehdi Azizi, Fereidoun J Res Med Sci Original Article BACKGROUND: Pathogenesis of cardiovascular diseases (CVDs) may be indicated by lipoprotein-associated phospholipase A2 (Lp-PLA2), serving as an inflammatory biomarker. However, the general dietary predictors of Lp-PLA2 have not been investigated so far. The aim of the present study is to investigate the relationship between the serum levels of Lp-PLA2 and dietary patterns in adults with cardiovascular risk factors. MATERIALS AND METHODS: Dietary patterns extracted using factor analysis and serum levels of Lp-PAL2 in 470 adults aged 40–70 years who participated in the 5(th) phase of the Tehran Lipid and Glucose Study (2011–2014) were determined. Associations between the dietary patterns and serum levels of Lp-PAL2 considering some confounder factors were evaluated. RESULTS: The results showed that Western and semi-Mediterranean dietary patterns had significant effects on changes in Lp-PLA2 levels in univariate analyses. In multivariate analyses, after adjusting for age, sex, total cholesterol, low-density lipoprotein cholesterol, body mass index and physical activity, energy intake, hormone therapy for women, and taking blood lipid-lowering drugs as potential confounders, the Western dietary pattern remained a significant factor influencing the Lp-PLA2 level (β value: 1.65, 95% confidence interval: 1.12, 1.89; P < 0.05). Moreover, after adjustment for the mentioned confounder factors, the effect of the semi-Mediterranean dietary pattern on Lp-PLA2 disappeared. CONCLUSION: It can be concluded that the Western dietary pattern is associated with higher Lp-PLA2 levels. We recommend that adults eat less carbonated drinks, fast foods, salty snacks, mayonnaise, and organ meat to counteract increased serum Lp-PLA2 levels, which are directly associated with vascular inflammation and CVDs. Wolters Kluwer - Medknow 2020-01-20 /pmc/articles/PMC7003539/ /pubmed/32055243 http://dx.doi.org/10.4103/jrms.JRMS_256_19 Text en Copyright: © 2020 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Seyedi, Seyed Hashem Sezavar
Mottaghi, Azadeh
Mirmiran, Parvin
Hedayati, Mehdi
Azizi, Fereidoun
The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study
title The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study
title_full The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study
title_fullStr The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study
title_full_unstemmed The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study
title_short The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study
title_sort relationship between dietary patterns and lipoprotein-associated phospholipase a2 levels in adults with cardiovascular risk factors: tehran lipid and glucose study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003539/
https://www.ncbi.nlm.nih.gov/pubmed/32055243
http://dx.doi.org/10.4103/jrms.JRMS_256_19
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