Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release

The Chinese hamster ovary (CHO) cells used to produce biopharmaceutical proteins are known to contain type‐C endogenous retrovirus (ERV) sequences in their genome and to release retroviral‐like particles. Although evidence for their infectivity is missing, this has raised safety concerns. As the gen...

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Detalles Bibliográficos
Autores principales: Duroy, Pierre‐Olivier, Bosshard, Sandra, Schmid‐Siegert, Emanuel, Neuenschwander, Samuel, Arib, Ghislaine, Lemercier, Philippe, Masternak, Jacqueline, Roesch, Lucien, Buron, Flavien, Girod, Pierre‐Alain, Xenarios, Ioannis, Mermod, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003738/
https://www.ncbi.nlm.nih.gov/pubmed/31631325
http://dx.doi.org/10.1002/bit.27200

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