N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

Herein, the application of N‐hydroxysuccinimide‐modified phosphonamidate building blocks for the incorporation of cysteine‐selective ethynylphosphonamidates into lysine residues of proteins, followed by thiol addition with small molecules and proteins, is reported. It is demonstrated that the buildi...

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Detalles Bibliográficos
Autores principales: Kasper, Marc‐André, Gerlach, Marcus, Schneider, Anselm F. L., Groneberg, Christiane, Ochtrop, Philipp, Boldt, Stefanie, Schumacher, Dominik, Helma, Jonas, Leonhardt, Heinrich, Christmann, Mathias, Hackenberger, Christian P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003776/
https://www.ncbi.nlm.nih.gov/pubmed/31661184
http://dx.doi.org/10.1002/cbic.201900587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003776/
https://www.ncbi.nlm.nih.gov/pubmed/31661184
http://dx.doi.org/10.1002/cbic.201900587

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