Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid

Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disease arising from mutations in the dystrophin gene. Upregulation of utrophin to compensate for the missing dystrophin offers a potential therapy independent of patient genotype. The first‐in‐class utrophin modulator ezutromid/SMT C1100 w...

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Detalles Bibliográficos
Autores principales: Wilkinson, Isabel V. L., Perkins, Kelly J., Dugdale, Hannah, Moir, Lee, Vuorinen, Aini, Chatzopoulou, Maria, Squire, Sarah E., Monecke, Sebastian, Lomow, Alexander, Geese, Marcus, Charles, Philip D., Burch, Peter, Tinsley, Jonathan M., Wynne, Graham M., Davies, Stephen G., Wilson, Francis X., Rastinejad, Fraydoon, Mohammed, Shabaz, Davies, Kay E., Russell, Angela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003794/
https://www.ncbi.nlm.nih.gov/pubmed/31755636
http://dx.doi.org/10.1002/anie.201912392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003794/
https://www.ncbi.nlm.nih.gov/pubmed/31755636
http://dx.doi.org/10.1002/anie.201912392

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